Journal of labelled compounds and radiopharmaceuticals p. 989 - 996 (2000)
Update date:2022-08-05
Topics:
Vos, F. De
Dumont, F.
Santens, P.
Slegers, G.
Dierckx, R. A.
Reuck, J. De
The synthesis of two 11C labelled chromeno[3,4-c]pyridin-5-ones for the visualisation of the dopamine D4 receptor subtype has been developed. The production entailed an (9-methylation of the O-desmethyl precursor with [11C]iodomethane in the presence of tetrabutylammonium hydroxide. Subsequent purification by RP-HPLC and formulation by tracer enrichment on a CIS Sep Pak provided a solution which was suitable for human iv injection. Specific activity of the tracer averaged 37 GBq/μmol at EOS and the radiochemical yields were 65 percent (decay-corrected, based on [11C]CH3I). Total activity obtained was 5.6 - 7.4 GBq. The preparations have been demonstrated to be chemically and radiochemically pure by HPLC.
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Doi:10.1002/1521-3749(200010)626:10<2136::aid-zaac2136>3.0.co;2-j
(2000)Doi:10.1080/00945710009351854
(2000)Doi:10.1007/BF00764287
()Doi:10.1021/jo0002644
(2000)Doi:10.1134/S1070428009110311
(2009)Doi:10.1016/S0022-328X(00)00295-3
(2000)
