Phenylpiperazine derivatives with strong affinity for 5HT(1A), D(2A) and D3 receptors

Article abstract of DOI:10.1016/S0960-894X(98)00646-5

Four 7-[3-(4-phenyl-1-piperazinyl)propoxy]coumarins were synthesized. The affinities of these compounds for DA (D(2A), D₃) and 5HT(1A) receptors were evaluated for their ability to displace [³H]-raclopride and [³H]-8- OH-DPAT respectively from their specific binding sites. The affinities of the target compounds were all in the nanomolar range and followed the order 5- HT(1A) > D2 > D3.