Bioorganic and Medicinal Chemistry Letters p. 3567 - 3570 (1998)
Update date:2022-07-31
Topics:
Teran, Carmen
Santana, Lourdes
Uriarte, Eugenio
Fall, Yagamare
Unelius, Lena
Tolf, Bo-Ragnar
Four 7-[3-(4-phenyl-1-piperazinyl)propoxy]coumarins were synthesized. The affinities of these compounds for DA (D(2A), D3) and 5HT(1A) receptors were evaluated for their ability to displace [3H]-raclopride and [3H]-8- OH-DPAT respectively from their specific binding sites. The affinities of the target compounds were all in the nanomolar range and followed the order 5- HT(1A) > D2 > D3.
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