12. Approaches to the Synthesis of Cytochalasans. Part 2. Pyrrolinone Derivatives as Basic Units

Article abstract of DOI:10.1002/hlca.19800630113

Several attempts to prepare 3-acetyl-5-benzyl-3-pyrrolin-2-one (7) from phenylalanine are described.This goal was only reached formally, because compound 7 exists in the tautomeric form of (Z)-5-benzyl-3-(1'-hydroxyethylidene)-4-pyrrolin-2-one (17) according to the spectral data.The problem of tautomerism in pyrrolinone systems is discussed.