A total synthesis and structural aspects of racemic 8-oxygenated tetracyclines

DOI: 10.1021/ja00502a039

Source and publish data:

Journal of the American Chemical Society p. 2171 - 2181 (1979)

Update date:2022-07-30

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Authors:

Glatz Glatz

Helmchen

Muxfeldt

et al. et al.

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Article abstract of DOI:10.1021/ja00502a039

A stereoselective total synthesis of the first 8-oxygenated tetracycline derivatives 43 and 4 is described. Key steps for the construction of the tetracycline skeleton are the condensation of the tetralone aldehyde 24 with the thiazolone 32 followed by co

Full text of DOI:10.1021/ja00502a039

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