Bioorganic and Medicinal Chemistry Letters p. 1529 - 1534 (1996)
Update date:2022-08-05
Topics:
Blythin, David J.
Kuo, Shen-Chun
Shue, Ho-Jane
McPhail, Andrew T.
Chapman, Richard W.
Kreutner, William
Rizzo, Charles
She, Hoyan S.
West, Robert
The synthesis and GABA(B) antagonist activity of a series of substituted morpholine-2-acetic acid derivatives is described. Resolution of the lead compound from the series produces one active and one inactive enantiomer. X- ray analysis of a halogenated derivative (25) of the active enantiomer Sch 50911 (23) shows that it possesses the 2S configuration.
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