Communication
ChemComm
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17 L. A. P. Antony, T. Slanina, P. Sebej, T. Solomek and P. Klan, Org.
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suggest that COFP and other related nitro-based CO probes are
capable of sensing only CO from ruthenium-based CO-RMs, as
described in the original papers, but is not a general CO probe.
Fig. S19 (ESI†) summarizes the key findings of this study.
In conclusion, we found that arylnitro reduction-based CO
probes do not respond to CO in general. CO alone cannot reduce
the arylnitro group, which is the chemical event necessary for
turning on the fluorescent probe. Our studies coupled with literature
precedents revealed the requirement for a ruthenium carbonyl
moiety for the reduction of an arylnitro group. As a result, nitro
reduction-based CO probes only sense ruthenium-based CO donors,
CORM-2 and CORM-3, not CO in general. The new insights into the
nitro-based CO probes define their scope of applications and lend a
mechanistic understanding of the reduction of an arylnitro group by
CO in the context of biological applications. Additionally, such
studies also indicate the need to use CO from various sources in
future assessment of new CO probes.
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BW and LKDLC are partially supported by a grant from the
National Institutes of Health (R01DK119202) on CO-related
work. We also acknowledge the financial support from Georgia
State University and the Georgia Research Alliance through an
Eminent Scholar endowment (BW), a Brains & Behavior Fellow-
ship to Z. Y. and a CDT Fellowship to LKDLC.
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Conflicts of interest
There are no conflicts to declare.
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