Journal of Organic Chemistry p. 1610 - 1612 (1982)
Update date:2022-09-26
Topics:
Kempf, Dale J.
Wilson, Kenneth D.
Beak, Peter
Novel β' metalations of the α,β-unsaturated tertiary amides N,N-diisopropyl-1-cyclohexenecarboxamide (3), (E)-N,N-diisopropyl-2-methyl-2-butenamide (7), and N,N-diisopropyl-6-(trimethylsilyl)-1-cyclohexenecarboxamide (10) are reported.Additions of the β'-lithio-α,β-unsaturated tertiary amides 4, 8, and 11 to a variety of electrophiles, including in the case of 8 subsequent formation of five-membered rings, illustrate the value of this approach for achieving substitution at the β' position of α,β-unsaturated carboxylic acid derivatives.
View MoreLaohekou huacheng Trade Co., Ltd.
Contact:+86-710-8360685
Address:No. 85, Beijing Road, Laohekou City, Hubei Province, China
Hubei Xinghuo Chemical Co., Ltd.,
Contact:13925817279 13907299441
Address:Xinghuo Fine Chemistry Industrial Park, Xiaochang County, Hubei Province, China
Ningbo Inno Pharmchem Co., Ltd.
Contact:86-574-87319282
Address:6F-5,NO.163 RUIQING RD.,NINGBO 315000 CHINA
Contact:86-21-34622192,13917187091,21-34622765
Address:No. 500 Caobao Road Shanghai P.R China
shandong zhongke taidou chemical co.,ltd
Contact:86-531-88682301
Address:Jinan shandong Province CHina
Doi:10.1016/j.bmcl.2004.09.050
(2004)Doi:10.1021/ja0483037
(2004)Doi:10.1021/jo01308a031
(1980)Doi:10.1021/ja070516j
(2007)Doi:10.1248/cpb.51.1413
(2003)Doi:10.1021/ja01272a042
(1938)