Chemical and Pharmaceutical Bulletin p. 2314 - 2317 (1996)
Update date:2022-07-29
Topics:
Niwa, Ryuji
Kamada, Hitoshi
Shitara, Eiki
Horiuchi, Jiro
Kibushi, Nobuyuki
Kato, Tetsuzo
The reaction of cyanogen bromide (1) with primary amines (2a-p), including arylmethylamines (21-p), gave the corresponding cyanamides (3a- p). Trimerization of 3a-p gave 1,3,5-trisubstituted 2,4,6-triiminohexahydro- 1,3,5-triazines (isomelamines) (4a-p), which were treated with hydrochloric acid to give the corresponding 1,3,5-trisubstituted 2,4,6-trioxohexahydro- 1,3,5-triazines (isocyanurates) (5a-c, f) and 1,3,5-trisubstituted 2-imino- 4,6-dioxohexahydro-1,3,5- triazines (5b'-e'). Biological evaluation of 4a- p, 5a-c, f, and 5b'-e' was carried out, and some of these compounds showed bronchodilator and positive inotropic activities.
View MoreContact:86-510-82853889
Address:Rm.3732, No.18-2,Yonghe Rd.,Wuxi,Jiangsu,214023,China
Contact:+65 9658 0999
Address:26 Sin Ming Lane, Midview City, #05-118, Singapore 573971
Contact:+86-717-6370352
Address:168 Chengdong Avenue, Yichang, Hubei 443003, P. R.China
Shanggao Ruiya Fine Chemicals Co., Ltd
Contact:+86-795-2592103
Address:Xingguang Nanlu,Shanggao County Industry Park
Shanghai Hanhong Scientific Co.,Ltd.
website:http://www.chemvia.com
Contact:+86-21-64541543,54280654,13918533501
Address:Jiachuan Road 245
Doi:10.1021/om050647y
(2005)Doi:10.1055/s-2005-918923
(2005)Doi:10.1016/j.bmcl.2005.09.027
(2006)Doi:10.1055/s-0030-1260156
(2011)Doi:10.1023/B:RUGC.0000039093.42205.e6
(2004)Doi:10.1039/jr9390000307
(1939)
