Chemical and Pharmaceutical Bulletin p. 2314 - 2317 (1996)
Update date:2022-07-29
Topics:
Niwa, Ryuji
Kamada, Hitoshi
Shitara, Eiki
Horiuchi, Jiro
Kibushi, Nobuyuki
Kato, Tetsuzo
The reaction of cyanogen bromide (1) with primary amines (2a-p), including arylmethylamines (21-p), gave the corresponding cyanamides (3a- p). Trimerization of 3a-p gave 1,3,5-trisubstituted 2,4,6-triiminohexahydro- 1,3,5-triazines (isomelamines) (4a-p), which were treated with hydrochloric acid to give the corresponding 1,3,5-trisubstituted 2,4,6-trioxohexahydro- 1,3,5-triazines (isocyanurates) (5a-c, f) and 1,3,5-trisubstituted 2-imino- 4,6-dioxohexahydro-1,3,5- triazines (5b'-e'). Biological evaluation of 4a- p, 5a-c, f, and 5b'-e' was carried out, and some of these compounds showed bronchodilator and positive inotropic activities.
View MoreSEA BRGIHT INDUSTRY CO.,LIMITED
Contact:0086 755 8622 3990
Address:Rm 17B3,GuangCaiXinTianDi Bldg,GuiMiao Rd,NanShan District,Shenzhen,China
Zhejiang Tianyu Pharmaceutical Co., Ltd.
Contact:+86-576-84177669, 89189665,89189688,84168770
Address:Jiangkou Development Zone, Huangyan, Taizhou City, Zhejiang
taizhou creating bio-pharm co.,ltd.
Contact:+86- 576- 88827176
Address:715 room ,unit A.junyue Building,Jiaojiang,Taizhou,Zhejiang,China
Contact:13813902930 025-52714267
Address:20 Fengji Road, Yuhua Economic Development Zone, Nanjing, Jiangsu, P. R. China
Shijiazhuang Frontierchem Co., Ltd.
Contact:+86-311-89271196
Address:4-4-202 No.15 Biandian Street,Shijiazhuang
Doi:10.1021/om050647y
(2005)Doi:10.1055/s-2005-918923
(2005)Doi:10.1016/j.bmcl.2005.09.027
(2006)Doi:10.1055/s-0030-1260156
(2011)Doi:10.1023/B:RUGC.0000039093.42205.e6
(2004)Doi:10.1039/jr9390000307
(1939)
