Ortho -Naphthoquinone-catalyzed aerobic oxidation of amines to fused pyrimidin-4(3 H)-ones: A convergent synthetic route to bouchardatine and sildenafil

DOI: 10.1039/d0ra06820a

Source and publish data:

RSC Advances p. 31101 - 31105 (2020)

Update date:2022-07-31

Topics:

Authors:

Kim, Hun Young

Kim, Kyeongha

Oh, Kyungsoo

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Article abstract of DOI:10.1039/d0ra06820a

A facile access to fused pyrimidin-4(3H)-one derivatives has been established by using the metal-free ortho-naphthoquinone-catalyzed aerobic cross-coupling reactions of amines. The utilization of two readily available amines allowed a direct coupling strategy to quinazolinone natural product, bouchardatine, as well as sildenafil (Viagra) in a highly convergent manner. This journal is

Full text of DOI:10.1039/d0ra06820a

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