AN ENANTIOSELECTIVE SYNTHESIS OF THE C(10) TO C(23) BACKBONE OF THE POTENT IMMUNOSUPPRESSANT FK506

Article abstract of DOI:10.1016/S0040-4039(01)80352-X

The C(10) to C(23) fragment of FK506 has been pepared in a convergent, highly stereocontrolled, fashion.The key transformations entailed opening of a symmetrical trans-disubstituted epoxide with a trisubstituted vinylalane ate complex, the reductive remov