First evaluation of acyloxymethyl or acylthiomethyl groups as biolabile 2′-O-protections of RNA

DOI: 10.1021/ol0616182

Source and publish data:

Organic Letters p. 3869 - 3872 (2006)

Update date:2022-08-05

Topics:

Authors:

Parey, Nora

Baraguey, Carine

Vasseur, Jean-Jacques

Debart, Francoise

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Article abstract of DOI:10.1021/ol0616182

Short oligo-U sequences containing 2′-O-acyloxymethyl or acylthiomethyl groups as biolabile 2′-O-protections of RNA have been synthesized. These modified homouridylates are deprotected upon cellular esterase activation to release the parent RNA. They exhi

Full text of DOI:10.1021/ol0616182

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