Enzyme-Catalyzed Enantioconvergent Lactonization of γ-Hydroxy Diesters in Organic Solvents

DOI: 10.1021/jo00279a002

Source and publish data:

Journal of Organic Chemistry p. 4263 - 4265 (1989)

Update date:2022-07-29

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Authors:

Gutman, Arie L.

Bravdo, Tamar

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Article abstract of DOI:10.1021/jo00279a002

A strategy has been developed for the enantioconvergent lactonization of symmetrical hydroxy diesters which exploits the prochiral stereospecificity of lipases in organic solvents.Using this approach, prochiral γ-hydroxypimelate diesters (2) were converte

Full text of DOI:10.1021/jo00279a002

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