A mild and efficient method for selective cleavage of ketals and acetals using lithium chloride in water - Dimethyl sulfoxide

Article abstract of DOI:10.1016/S0040-4039(97)01689-4

A mild anil efficient neutral aqueous method for selective cleavage of acetals and ketals to the corresponding carbonyl compounds has been established by using LiCI in H₂O-DMSO at elevated temperature. While aryl and α,β-unsaturated ketals and acetals underwent smooth cleavage, diaryl, non-aryl and isolated ketals and acetals remained unaffected under the reaction conditions.