
Synthetic Communications p. 1933 - 1939 (1999)
Update date:2022-08-17
Topics:
Fleming
Dyer
Eggington
Racemic 6-gingerol can be obtained in a one-pot reaction by hexanal addition to the dianion of zingerone at low temperature. Similarly, addition of octanal or decanal to the dianion provides 8-gingerol or 10-gingerol, respectively. Acid treatment of the gingerols allows for formation of the corresponding shogaols.
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