Synthesis of 7-Fluoro-2,4-methylene-17,20-dimethylprostacyclins. Novel Stable Prostacyclin Analogs as Potent Anti-anginal Agents

Article abstract of DOI:10.1016/0040-4020(95)00468-N

Synthesis of new stable fluoroprostacyclins, 7-fluoro-2,4-methylene-17,20-dimethylprostacyclins (1, 2) with potent and long-lasting anti-anginal activities has been achieved.The cyclobutylene prostaglandin skeleton 10 was constructed efficiently according