Synthesis of 7-Fluoro-2,4-methylene-17,20-dimethylprostacyclins. Novel Stable Prostacyclin Analogs as Potent Anti-anginal Agents

DOI: 10.1016/0040-4020(95)00468-N

Source and publish data:

Tetrahedron p. 8771 - 8782 (1995)

Update date:2022-08-17

Topics:

Authors:

Matsumura, Yasushi

Shimada, Toyomichi

Nakayama, Toshiaki

Urushihara, Masahiro

Asai, Tomoyuki

et al. et al.

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Article abstract of DOI:10.1016/0040-4020(95)00468-N

Synthesis of new stable fluoroprostacyclins, 7-fluoro-2,4-methylene-17,20-dimethylprostacyclins (1, 2) with potent and long-lasting anti-anginal activities has been achieved.The cyclobutylene prostaglandin skeleton 10 was constructed efficiently according

Full text of DOI:10.1016/0040-4020(95)00468-N

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