Alternative Procedures for the Macrolactamisation of ω-Azido Acids

Article abstract of DOI:10.1016/S0040-4039(00)60653-6

ω-Azido acids, after activation of the carboxyl groups as mixed anhydrides, N3(CH2)nCOOCOAr (Ar = 3,5-dinitrophenyl or 2,4,6-trichlorophenyl), can be converted to macrolactams in good yields by treatment with Bu3P under high-dilution conditions; the prese