Synthesis and cytotoxicity of analogues of the antibiotic BE 10988 inhibitors of DNA topoisomerase II

DOI: 10.1016/S0960-894X(99)00307-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2025 - 2030 (1999)

Update date:2022-08-10

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Authors:

Catrycke, Marc-Olivier

Houssin, Raymond

Henichart, Jean-Pierre

Pfeiffer, Bruno

Renard, Pierre

Dassonneville, Laurent

Bailly, Christian

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Article abstract of DOI:10.1016/S0960-894X(99)00307-8

Indolequinone derivatives of the antitumour antibiotic BE 10988 were synthesized and evaluated for their cytotoxicity and action mechanism. The quinone system is essential to biological activity and the thiazole ring plays a major role in the poisoning of

Full text of DOI:10.1016/S0960-894X(99)00307-8

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