Rhodium-Catalysed Redox Isomerization of Hydroxy Alkynes to Trans Keto and Hydroxy Vinyl Esters. A Short and Stereoselective Synthesis of Dipeptide Isosters

Article abstract of DOI:10.1016/0040-4039(95)00768-8

Tris(triphenylphosphine)Rhodium(I) Chloride in the presence trialkyl phosphine catalyses the isomerization of hydroxy alkynes to unsaturated trans keto and hydroxy esters depending on the nature of the phosphine.Dipeptide isosters were obtained in an efficient manner by the application of this methodology.