Discovery of High-Affinity Inhibitors of the BPTF Bromodomain

DOI: 10.1021/acs.jmedchem.1c00721

Source and publish data:

Journal of Medicinal Chemistry p. 12075 - 12088 (2021)

Update date:2022-08-29

Topics:

Authors:

Lu, Tian

Lu, Haibo

Duan, Zhe

Wang, Jun

Han, Jie

Xiao, Senhao

Chen, HuanHuan

Jiang, Hao

Chen, Yu

Yang, Feng

Li, Qi Li, Qi

Chen, Dongying

Lin, Jin

Li, Bo Li, Bo

Jiang, Hualiang

Chen, Kaixian

Lu, Wenchao

Lin, Hua

Luo, Cheng

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Article abstract of DOI:10.1021/acs.jmedchem.1c00721

The dysfunctional bromodomain PHD finger transcription factor (BPTF) exerts a pivotal influence in the occurrence and development of many human diseases, particularly cancers. Herein, through the structural decomposition of the reported BPTF inhibitor TP-

Full text of DOI:10.1021/acs.jmedchem.1c00721

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