Selective conjugate alkylation of alkyllithium nucleophiles to α, β, γ, δ-unsaturated aldehydes with functionalized Lewis acid receptors

Article abstract of DOI:10.1246/cl.1998.403

Selective 1,4- and 1,6-addition of alkyllithium reagents to α,β,γ,δ-unsaturated aldehydes has been successfully realized with fluorinated aluminum tris(2,6-diphenylphenoxide) (ATPH) derivatives as functionalized Lewis acid receptors.