Facile synthesis of N-(1-alkenyl) derivatives of 2,4-pyrimidinediones

Article abstract of DOI:10.1080/15257770008035032

N-(1-alkenyl) derivatives of 2,4-pyrimidinediones (6 - 9) were prepared in a one pot synthesis from aldehydes and the nucleobases using trimethylsilyl trifluoromethanesulfonate (TfOTMS) as coupling reagent. Presilylation of the above nucleobases, and N⁶-benzoyladenine, with excess N,O-bis(trimethylsilyl)acetamide (BSA) followed by addition of one mol eq. TfOTMS yielded the N-(1-trimethylsilyloxyalkyl) derivatives 1 - 5.

Full text of DOI:10.1080/15257770008035032

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Nucleosides, Nucleotides and Nucleic
Acids
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Facile Synthesis of N-(1-Alkenyl)
Derivatives of 2,4-Pyrimidinediones
a
Ulla Henriksen
a
Department of Chemistry , University of Copenhagen The H. C.
Ørsted Institute , Universitetsparken 5, DK-2100, Copenhagen,
Denmark
Published online: 05 Nov 2010.
To cite this article: Ulla Henriksen (2000) Facile Synthesis of N-(1-Alkenyl) Derivatives of
2
1
,4-Pyrimidinediones, Nucleosides, Nucleotides and Nucleic Acids, 19:7, 1093-1100, DOI:
0.1080/15257770008035032
To link to this article: http://dx.doi.org/10.1080/15257770008035032
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