ONE ELECTRON TRANSFER MECHANISM IN THE ENZYMATIC OXYGENATION OF SULFOXIDE TO SULFONE PROMOTED BY A RECONSTITUTED SYSTEM WITH PURIFIED CYTOCHROME P-450

Article abstract of DOI:10.1016/S0040-4039(00)86881-1

A kinetic study on enzymatic S-oxygenation of sulfoxides to sulfones was carried out by a reconstituted system with purified cytochrome P-450.A linear correlation observed between log(Vmax)'s and the one-electron oxidation potentials of sulfoxides suggests that the oxygenation of sulfoxides proceeds via one electron transfer process to the active "oxenoid" intermediate of the enzyme.