Synthesis of tight binding inhibitors and their action on the proprotein- processing enzyme furin

Article abstract of DOI:10.1021/jm00020a016

Furin is a subtilisin-like eukaryotic serine endoprotease which processes proproteins to biologically active proteins and peptides. Also, the envelope proteins of viruses, such as influenza and HIV viruses, need to be processed by furin for infectivity. T