An expedient synthesis of ethyl 4(5)-alkyl(aryl)thioimidazole-5(4)-carboxylate

DOI: 10.1055/s-1995-3975

Source and publish data:

Synthesis p. 635 - 637 (1995)

Update date:2022-08-10

Topics:

Authors:

Caille Caille

Didierlaurent

Lefrancois

Lelievre

Sury Sury

Aszodi Aszodi

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Article abstract of DOI:10.1055/s-1995-3975

Various ethyl 4-alkyl(aryl)thioimidazole-5-carboxylates have been synthesized by the reaction of ethyl valeramidocyanoacetate with a variety of alkyl(aryl) thiols in the presence of triethylamine and subsequent phosphorus pentachloride/4-dimethylaminopyridine (DMAP) mediated cyclization of the acyclic intermediates.

Full text of DOI:10.1055/s-1995-3975

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