Bioorganic and Medicinal Chemistry Letters p. 1595 - 1600 (1996)
Update date:2022-08-11
Topics:
Groves, John T.
Matsunaga, Akio
The first example of DNA double-strand cleavage mediated by a synthetic porphyrin is described. Two new porphyrins, each with two metal complexing appendages, were shown to mediate the oxidative double-strand cleavage of pBR322 plasmid DNA. By contrast, a porphyrin with one appendage was found to mediate only single-strand breaks.
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