6N-cinnamoyl-β-naltrexamine and its p-nitro derivative. High efficacy κ-opioid agonists with weak antagonist actions

DOI: 10.1016/0960-894X(95)00583-F

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 167 - 172 (1996)

Update date:2022-08-31

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Authors:

Derrick, Ian

Moynihan, Humphrey A.

Broadbear, Jillian

Woods, James H.

Lewis, John W.

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Article abstract of DOI:10.1016/0960-894X(95)00583-F

6N-cinnamoyl-β-naltrexamine and its p-nitro derivative (7 and 8) are κ-opioid agonists of high potency and exceptional efficacy and are only weakly effective μ opioid antagonists. This contrasts with the p-methyl analogue which has only low efficacy κ-ago

Full text of DOI:10.1016/0960-894X(95)00583-F

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