NTP Carcinogenesis Bioassay (feed); Clear Evidence: mouse, Some Evidence: rat NTPTR*    National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. NTP-TR-475 ,1998. . Reported in EPA TSCA Inventory.

OSHA PEL: TWA 200 ppm; STEL 250 ppm
ACGIH TLV: TWA 200 ppm; STEL 250 ppm; BEI: 8 mg/L tetrahydrofuran in urine at end of shift
DFG MAK: 50 ppm (150 mg/m³)
DOT Classification:  3; Label: Flammable Liquid

  Tetrahydrofuran (CAS NO.109-99-9), its  occupational chemical analysis use NIOSH: Tetrahydrofuran, 1609.

Tetrahydrofuran (THF) is an organic compound with the formula (CH₂)₄O. It is a colorless, water-miscible organic liquid with low viscosity at standard temperature and pressure. The compound is heterocyclic. As one of the most polar ethers with a wide liquid range, it is a useful solvent. With the CAS NO.109-99-9, it is also called 1,4-Epoxybutane ; AI3-07570 ; Agrisynth THF ; Butane, 1,4-epoxy- ; Butane, alpha,delta-oxide ; Butylene oxide ; CCRIS 6276 ; Cyclotetramethylene oxide ; Diethylene oxide.

Physical properties about Tetrahydrofuran are: (1)ACD/LogP: 0.473; (2)ACD/LogD (pH 5.5): 0.47; (3)ACD/LogD (pH 7.4): 0.47; (4)ACD/BCF (pH 5.5): 1.35; (5)ACD/BCF (pH 7.4): 1.35; (6)ACD/KOC (pH 5.5): 43.07; (7)ACD/KOC (pH 7.4): 43.07; (8)#H bond acceptors: 1; (9)Index of Refraction: 1.417; (10)Molar Refractivity: 20.052 cm³; (11)Molar Volume: 79.76 cm³; (12)Polarizability: 7.949 10-24cm³; (13)Surface Tension: 28.8099994659424 dyne/cm; (14)Density: 0.904 g/cm³; (15)Flash Point: -17.222 °C; (16)Enthalpy of Vaporization: 29.81 kJ/mol; (17)Boiling Point: 68.278 °C at 760 mmHg; (18)Vapour Pressure: 152.442993164063 mmHg at 25°C

Preparation of Tetrahydrofuran: Tetrahydrofuran (CAS NO.109-99-9) can be manufactured from butane by using circulating solids technology in which butane is oxidized to maleic acid and thence to tetrahydrofuran


Uses of Tetrahydrofuran:  The main application of Tetrahydrofuran (CAS NO.109-99-9) is as an industrial solvent for PVC and in varnishes.
Tetrahydrofuran(CAS NO.109-99-9) can be polymerized by strong acids to give a linear polymer called poly(tetramethylene ether) glycol (PTMEG), also known as PTMO, polytetramethylene oxide. The primary use of this polymer is to make elastomeric polyurethane fibers like Spandex. THF can be used in hydroboration reactions to synthesize primary alcohols, and as a solvent for organometallic compounds such as organolithium and Grignard reagents. It is often used in polymer science. It can be used to liquefy old PVC cement, and is often used industrially to degrease metal parts.

When you are using this chemical, please be cautious about it as the following:
1. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;
2. Wear suitable protective clothing;
3. Take precautionary measures against static discharges;
4. Do not empty into drains;
5. Keep away from sources of ignition - No smoking;

You can still convert the following datas into molecular structure:
(1)InChI=1S/C4H8O/c1-2-4-5-3-1/h1-4H2;
(2)InChIKey=WYURNTSHIVDZCO-UHFFFAOYSA-N;
(3)SmilesC1CCOC1

The toxicity data is as follows: