Hit Identification

Medicinal chemistry Molecular docking nonpeptide inhibitors binding affinity X-ray crystallography Purification Starting Material Structure-Activity Relationship (SAR) Analysis Preclinical and Clinical Studies Chemical Synthesis Biological Assays Structure-Activity Relationship (SAR) Studies Clinical Trials High-Throughput Screening Clinical Development Lead Optimization Subsequent Transformations Lead Compound Selection FDA Approval Formulation Development Virtual Screening De Novo Design Preclinical and Clinical Development Regulatory Approval In Vitro Assays Toxicity and Safety Evaluation Preclinical Testing Pharmacokinetics and Pharmacodynamics High-Throughput Screening (HTS) Target Identification and Validation Post-Market Surveillance In Vivo Assays In Vitro and In Vivo Testing In Vitro and In Vivo Assays Preclinical and Clinical Testing Target Identification Safety and Toxicology Studies Compound Screening