638-95-9Relevant articles and documents
Laird et al.
, p. 4108 (1960)
Synthesis of novel triterpene and N-allylated/N-alkylated niacin hybrids as α-glucosidase inhibitors
Narender, Tadigoppula,Madhur, Gaurav,Jaiswal, Natasha,Agrawal, Manali,Maurya, Chandan K.,Rahuja, Neha,Srivastava, Arvind K.,Tamrakar, Akhilesh K.
, p. 162 - 169 (2013)
Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia. α-Glucosidase (EC 3.2.1.20) inhibitors interfere with enzymatic action to slow down the liberation of d-glucose from oligosaccharides and disaccharides, resulting in delayed glucose absorption and decreased postprandial plasma glucose levels. In continuation of our drug discovery program on antidiabetic agents, we synthesized novel N-allylated/N-alkylated niacin and α-amyrin (4-9) and lupeol (12-16) hybrids and tested for their α-glucosidase inhibiting activity. Compounds 4-9 showed better activity profile than the marketed α-glucosidase inhibitor i.e. acarbose. Compound 4 possess the highest inhibitory action with IC50 of 5 μM. Kinetic and CD studies revealed that 4 inhibited the α-glucosidase in a noncompetitive manner and caused conformational changes in secondary structure of the enzyme protein.
Kohen,F. et al.
, p. 2710 - 2714 (1964)
Two triterpenyl fatty acid esters from fagonia cretica as lipoxygenase inhibitors
Nawaz, Zahid,Ahmed, Ejaz,Sharif, Ahsan,Sajid, Anam,Arshed, Faiza,Arshad, Muhammad,Anjum, Muhammad Imran,Razaq, Abdul
, p. 406 - 409 (2018/06/06)
Two triterpenyl fatty acid esters were isolated from the chloroform soluble fraction of Fagonia cretica and their structures elucidated as 3β-12-ursen-3yl-docosanoate (1) and 3β-12-ursen-3yl-nonacosanoate (2) by 1D-NMR, 2D-NMR, mass spectrometric and chemical analyses. Both new compounds were also evaluated for their lipoxygenase inhibitory potential using Baicalein as a standard.
Practical Synthesis of α-Amyrin, β-Amyrin, and Lupeol: The Potential Natural Inhibitors of Human Oxidosqualene Cyclase
Chen, Dongyin,Xu, Fengguo,Zhang, Pu,Deng, Jie,Sun, Hongbin,Wen, Xiaoan,Liu, Jun
, (2017/10/20)
A practical synthesis of α-amyrin (1), β-amyrin (2), and lupeol (3) was accomplished in total yields of 32, 42, and 40% starting from easily available ursolic acid (4), oleanolic acid (5), and betulin (6), respectively. Remarkably, these three natural pentacyclic triterpenes exhibited potential inhibitory activity against human oxidosqualene cyclase.