Dual catalyst cycle for the asymmetric benzylic functionalization process
June 13, 2024
Title:
Dual catalyst cycle for the asymmetric benzylic functionalization process
Image Source:
Asymmetric cross-coupling of aryl triflates to the benzylic position of benzylamines
Mark:
Scheme 1
Associated context:
We envisioned a novel and potentially very powerful dual catalyst cycle for the enantioselective functionalization of very weakly acidic benzylic C-H groups (Scheme 1). The left-hand cycle involves the palladium-catalyzed cross-coupling through oxidative addition to Pd0, transmetallation with M’ of the organometallic intermediate E to generate C, and reductive elimination to close the cycle.
