Proposed asymmetric arylation of tricarbonylchromium-stabilized benzyllithiums

June 13, 2024

• Title:       

  Proposed asymmetric arylation of tricarbonylchromium-stabilized benzyllithiums 

• Image Source:

  Asymmetric cross-coupling of aryl triflates to the benzylic position of benzylamines

• Mark:

  Scheme 3

• Associated context:

  First, the diarylmethane-based products in Scheme 2 are more acidic than the starting materials and might be expected to lead to the racemization of the enantioenriched products. Second, our proposed mechanism, described in more detail below  (Scheme 3), involves achieving enantioselectivity through a novel DKR.