Two different paths for the reaction of alkynals with a nucleophile under the catalysis of palladium

June 18, 2024

• Title:       

  Two different paths for the reaction of alkynals with a nucleophile under the catalysis of palladium 

• Image Source:

  An unexpected addition of acetic acid to ortho-electron-deficient alkynyl-substituted aryl aldehydes catalyzed by palladium(II) acetate

• Mark:

  Scheme 1

• Associated context:

  In the above-mentioned reactions, alcohols or indoles serve as nucleophiles to add to the aldehyde, promoting the aldehyde oxygen to attack the palladium-acti-vated carbon-carbon triple bond (Scheme 1, path b). In these reactions, the nucleophiles attack the palladium-activated carbon-carbon triple bond first and then add to the carbon-heteroatom multiple bonds (Scheme 1, path a).