Chiral diphenyl prolinol 8-catalyzed direct asymmetric α-amino-methylation of aldehydes 2

June 20, 2024

• Title:       

  Chiral diphenyl prolinol 8-catalyzed direct asymmetric α-amino-methylation of aldehydes 2

• Image Source:

  Direct catalytic enantioselective α-aminomethylation of aldehydes

• Mark:

  Table 3

• Associated context:

  With these results in hand, we decided to investigate the chiral pyrrolidine 8-catalyzed reaction between dibenzylaminomethyl ether 1 and different aldehydes 2 in the presence of LiBr (CAS 7550-35-8) (Table 3).