Possible reaction pathways for the hydrothiolation of double bounds

June 28, 2024

• Title:       

  Possible reaction pathways for the hydrothiolation of double bounds

• Image Source:

  Iron-catalysed Markovnikov hydrothiolation of styrenes

• Mark:

  Scheme 1

• Associated context:

  Following Markovnikov's rule, the oxygen nucleophile adds onto the more positive carbon but, in contrast, the addition of thiols can proceed in two ways: free-radical (pathway A) or electrophilic (pathway B, Scheme 1).