Rethrosynthetic Analysis for Achilleol B

July 17, 2024

• Title:       

  Rethrosynthetic Analysis for Achilleol B

• Image Source:

  First total synthesis of (-)-achilleol B: Reassignment of its relative stereochemistry

• Mark:

  Scheme 1

• Associated context:

  Thus, we anticipated that the tricyclic achillane skeleton might arise from the coupling of two C15 chiral synthons, namely, A  (nucleophilic where X = phenylsulfone) and B (electrophilic with Y = Br) (Scheme 1).