The chemistry started with the synthesis of a series of analogues

July 18, 2024

• Title:       

  The chemistry started with the synthesis of a series of analogues

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  Synthesis and structure-activity relationship studies of 2-(1,3,4-oxadiazole-2(3H)-thione)-3-amino-5-arylthieno[2,3-b]pyridines as inhibitors of DRAK2

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  Scheme 2

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  The chemistry started with the synthesis of a series of analogues with subtle structural variations in the phenyl moiety  (Scheme 2). Appropriate 2-fluorobenzonitriles 7 were used as a starting material which, upon treatment with ethyl thioacetate under basic conditions, afforded ethyl 3-amino-2-carboxyl-ate derivatives 8.