Optimization of the Mukaiyama-Michael Reaction

August 16, 2024

• Title:       

  Optimization of the Mukaiyama-Michael Reaction

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  Construction of higly functionalized diazoacetoacentates via catalytic Mukaiyama-Michael reactions

• Mark:

  Table 1

• Associated context:

  Thus, the reaction of 1 with 1.1 equiv of cyclohexenone in the presence of 3.0 mol % Sc(OTf)3 gave the Mukaiyama-Michael reaction product (6a) in only 43% isolated yield after subsequent hydrolysis (entry 1, Table 1).