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Cas Database

109-83-1

109-83-1

Identification

  • Product Name:2-Methylaminoethanol

  • CAS Number: 109-83-1

  • EINECS:203-710-0

  • Molecular Weight:75.1106

  • Molecular Formula: C3H9NO

  • HS Code:2922.19

  • Mol File:109-83-1.mol

Synonyms:(2-Hydroxyethyl)methylamine;(Hydroxyethyl)methylamine;2-Hydroxy-N-methylethylamine;2-Hydroxyethyl-N-methylamine;2-Methylamino-1-ethanol;2-N-Monomethylaminoethanol;Amietol M 11;AminoAlcohol MMA;Methyl(2-hydroxyethyl)amine;Methyl(hydroxyethyl)amine;Methyl(b-hydroxyethyl)amine;Methylaminoethanol;Methylethanolamine;Methylethylolamine;Monomethylaminoethanol;Monomethylethanolamine;N-Methyl-N-(2-hydroxyethyl)amine;N-Methylaminoethanol;N-Methylmonoethanolamine;N-Monomethylaminoethanol;N-Monomethylethanolamine;NMEA;NSC 62776;Yubao;b-(Methylamino)ethanol;

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Safety information and MSDS view more

  • Pictogram(s):CorrosiveC

  • Hazard Codes:C

  • Signal Word:Danger

  • Hazard Statement:H302 Harmful if swallowedH312 Harmful in contact with skin H314 Causes severe skin burns and eye damage

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled Fresh air, rest. Artificial respiration may be needed. Refer for medical attention. In case of skin contact Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . In case of eye contact First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. If swallowed Rinse mouth. Do NOT induce vomiting. Refer for medical attention . Exposure can cause irritation of eyes, nose and throat. (USCG, 1999) Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mg/kg up to 200 ml of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin bums with dry sterile dressings after decontamination ... . /Organic bases/Amines and related compounds/

  • Fire-fighting measures: Suitable extinguishing media To fight fire, used alcohol foam. Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as nitrogen oxides and carbon monoxide, may be formed when involved in fire. (USCG, 1999) Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Personal protection: complete protective clothing including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Cautiously neutralize remainder. Then wash away with plenty of water. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Separated from strong oxidants and acids.Materials which are toxic as stored or which can decompose into toxic components...should be stored in a cool well ventilated place, out of the direct rays of the sun, away from areas of high fire hazard, and should be periodically inspected. Incompatible materials should be isolated...

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

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  • Manufacture/Brand:Usbiological
  • Product Description:2-Methylaminoethanol
  • Packaging:2kg
  • Price:$ 456
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:2-(Methylamino)ethanol
  • Packaging:50ml
  • Price:$ 140
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:2-(Methylamino)ethanol >99.0%(GC)(T)
  • Packaging:25mL
  • Price:$ 20
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:2-(Methylamino)ethanol >99.0%(GC)(T)
  • Packaging:500mL
  • Price:$ 42
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:2-(Methylamino)ethanol ≥98%
  • Packaging:2l
  • Price:$ 83
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:2-(Methylamino)ethanol for synthesis. CAS 109-83-1, chemical formula CH NHCH CH OH., for synthesis
  • Packaging:8058021000
  • Price:$ 53.1
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:2-(Methylamino)ethanol for synthesis
  • Packaging:1 L
  • Price:$ 50.87
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:2-(Methylamino)ethanol ≥98%
  • Packaging:250ml
  • Price:$ 34.8
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:2-(Methylamino)ethanol for synthesis. CAS 109-83-1, chemical formula CH NHCH CH OH., for synthesis
  • Packaging:8058020100
  • Price:$ 31
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:2-(Methylamino)ethanol ≥98%
  • Packaging:25ml
  • Price:$ 19.1
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Relevant articles and documentsAll total 45 Articles be found

Blount,Openshaw,Todd

, p. 286,289 (1940)

Easton,Dillard

, p. 1807,1809 (1963)

Schiff's Bases as Intermediates in the Hydrolytic Decomposition of 2-Alkyl-3-methyl-1,3-oxazolidines in Aqueous Acid

Pihlaja, Kalevi,Parkkinen, Aija,Loennberg, Harri

, p. 1223 - 1226 (1983)

The kinetics for the hydrolysis of 2-alkyl-3-methyl-1,3-oxazolidines have been examined spectrophotometrically in acidic solutions.The decomposition of the substrates to 2-methylaminoethanol and the corresponding aldehydes have been shown to proceed via stable intermediates which are kinetically and u.v.-spectroscopically very similar to the acyclic cationic Schiff's base derived from isobutyraldehyde and 2-methoxyethylmethylamine.The mechanisms for the formation and breakdown of the Schiff's base intermediate are discussed on the basis of pH-rate profiles, activation parameters, salt effects, and solvent deuterium isotope effects.

Electrochemical Reductive N-Methylation with CO2Enabled by a Molecular Catalyst

Rooney, Conor L.,Wu, Yueshen,Tao, Zixu,Wang, Hailiang

supporting information, p. 19983 - 19991 (2021/12/01)

The development of benign methylation reactions utilizing CO2 as a one-carbon building block would enable a more sustainable chemical industry. Electrochemical CO2 reduction has been extensively studied, but its application for reductive methylation reactions remains out of the scope of current electrocatalysis. Here, we report the first electrochemical reductive N-methylation reaction with CO2 and demonstrate its compatibility with amines, hydroxylamines, and hydrazine. Catalyzed by cobalt phthalocyanine molecules supported on carbon nanotubes, the N-methylation reaction proceeds in aqueous media via the chemical condensation of an electrophilic carbon intermediate, proposed to be adsorbed or near-electrode formaldehyde formed from the four-electron reduction of CO2, with nucleophilic nitrogenous reactants and subsequent reduction. By comparing various amines, we discover that the nucleophilicity of the amine reactant is a descriptor for the C-N coupling efficacy. We extend the scope of the reaction to be compatible with cheap and abundant nitro-compounds by developing a cascade reduction process in which CO2 and nitro-compounds are reduced concurrently to yield N-methylamines with high monomethylation selectivity via the overall transfer of 12 electrons and 12 protons.

Discovery of benzimidazole analogs as a novel interleukin-5 inhibitors

Boggu, Pulla Reddy,Kim, Youngsoo,Jung, Sang-Hun

, (2019/08/12)

A series of novel hydroxyethylaminomethylbenzimidazole analogs 5a-y were synthesized and evaluated for their IL-5 inhibitory activity using pro-B Y16 cell line. Among them, 2-(((4-(cyclohexylmethoxy)-1H-benzo[d]imidazol-2-yl)methyl)amino)butan-1-ol (5e, 94.3% inhibition at 30 μM, IC50 = 3.5 μM, cLogP = 4.132) and 3-cyclohexyl-2-(((4-(cyclohexylmethoxy)-1H-benzo[d]imidazol-2-yl)methyl)amino) propan-1-ol (5k, 94.7% inhibition at 30 μM, IC50 = 5.0 μM, cLogP = 6.253) showed the most potent inhibitory activity. The essential feature of SAR (Fig. 5) indicated that the chromenone ring can be replaced by a benzimidazole ring to maintain the inhibitory activity. In addition, the hydroxyethylaminomethyl group was suitable for the IL-5 inhibitory activity. Moreover, the hydrophobic substituents on carbon play an important role in the IL-5 inhibitory activity of these analogs. However, N-substituted analogs did not improve inhibitory activity. In addition, MTT assay of 5e and 5k with normal B lymphoblasts revealed that they had no significant effects on cell viability.

Process route upstream and downstream products

Process route

(2-hydroxyethyl)(methyl)amine
109-83-1

(2-hydroxyethyl)(methyl)amine

tert-butyl 2-(methylamino)ethylcarbamate
122734-32-1

tert-butyl 2-(methylamino)ethylcarbamate

Conditions
Conditions Yield
ethyl 2-(benzyloxycarbonylamino)ethanoate
1145-81-9

ethyl 2-(benzyloxycarbonylamino)ethanoate

(2-hydroxyethyl)(methyl)amine
109-83-1

(2-hydroxyethyl)(methyl)amine

benzyl alcohol
100-51-6,185532-71-2

benzyl alcohol

Conditions
Conditions Yield
2-isopropyl-3-methyl-1,3-oxazolidine
88021-30-1

2-isopropyl-3-methyl-1,3-oxazolidine

(2-hydroxyethyl)(methyl)amine
109-83-1

(2-hydroxyethyl)(methyl)amine

benzaldehyde
100-52-7

benzaldehyde

Conditions
Conditions Yield
deuteroperchloric acid; at 29.9 ℃; Mechanism;
2-(methyl-piperonyl-amino)-ethanol
91247-76-6

2-(methyl-piperonyl-amino)-ethanol

acetic anhydride
108-24-7

acetic anhydride

(2-hydroxyethyl)(methyl)amine
109-83-1

(2-hydroxyethyl)(methyl)amine

piperonol
495-76-1

piperonol

Conditions
Conditions Yield
nachfolgend Erhitzen mit alkoh. Kalilauge;
<i>N</i>-(2-hydroxy-ethyl)-<i>N</i>-methyl-guanidine
13429-32-8

N-(2-hydroxy-ethyl)-N-methyl-guanidine

(2-hydroxyethyl)(methyl)amine
109-83-1

(2-hydroxyethyl)(methyl)amine

ammonia
7664-41-7

ammonia

urea
57-13-6

urea

Conditions
Conditions Yield
methanol
67-56-1

methanol

ethanolamine
141-43-5

ethanolamine

ethyleneimine
151-56-4,9002-98-6

ethyleneimine

piperazine
110-85-0

piperazine

1,4-diaza-bicyclo[2.2.2]octane
280-57-9,88935-43-7

1,4-diaza-bicyclo[2.2.2]octane

(2-hydroxyethyl)(methyl)amine
109-83-1

(2-hydroxyethyl)(methyl)amine

Conditions
Conditions Yield
With Cs-P-Si mixed-oxide; at 300 ℃; under 750.06 Torr; Title compound not separated from byproducts;
37 % Chromat.
6%
methanol
67-56-1

methanol

ethanolamine
141-43-5

ethanolamine

piperazine
110-85-0

piperazine

1,4-diaza-bicyclo[2.2.2]octane
280-57-9,88935-43-7

1,4-diaza-bicyclo[2.2.2]octane

(2-hydroxyethyl)(methyl)amine
109-83-1

(2-hydroxyethyl)(methyl)amine

Conditions
Conditions Yield
With H-β-zeolite; at 250 ℃; under 750.06 Torr; Title compound not separated from byproducts;
2%
But-(E)-ylidene-(2-hydroxy-ethyl)-methyl-ammonium; perchlorate

But-(E)-ylidene-(2-hydroxy-ethyl)-methyl-ammonium; perchlorate

(2-hydroxyethyl)(methyl)amine
109-83-1

(2-hydroxyethyl)(methyl)amine

isobutyraldehyde
78-84-2

isobutyraldehyde

Conditions
Conditions Yield
With perchloric acid; at 10.1 ℃; Kinetics; Mechanism; Thermodynamic data; ΔH(excit.); -ΔS(excit.); acidity, electrolyte and solvent deuterium isotope effects; different temperatures and acid concentrations;
1-methyltriazoline
136911-37-0

1-methyltriazoline

N-methylaziridine
1072-44-2

N-methylaziridine

(2-hydroxyethyl)(methyl)amine
109-83-1

(2-hydroxyethyl)(methyl)amine

acetaldehyde
75-07-0,9002-91-9

acetaldehyde

methylamine
74-89-5

methylamine

Conditions
Conditions Yield
With water; at 25 ℃; Rate constant; Product distribution; Mechanism; pH 10.75 (lysine buffer); other solvent, other pH (other buffers), H/D isotope effect;
tertamethylammonium iodide
75-58-1

tertamethylammonium iodide

ethanolamine
141-43-5

ethanolamine

(2-hydroxyethyl)(methyl)amine
109-83-1

(2-hydroxyethyl)(methyl)amine

trimethylamine
75-50-3

trimethylamine

Conditions
Conditions Yield
at 154 ℃; Rate constant;

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