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32315-10-9

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32315-10-9 Usage

Chemical Description

Different sources of media describe the Chemical Description of 32315-10-9 differently. You can refer to the following data:
1. Triphosgene is a chemical compound with the formula C3Cl6O3, which is used as a reagent in organic synthesis.
2. Triphosgene is a highly electrophilic reagent that is used to activate the carboxylate group in the alkali metal salt, leading to lactamization.
3. Triphosgene is a reagent used to convert amines to isocyanates.

Toxicity

As a common production raw material for chemical enterprises, Sanguang gas is not listed in the list of hazardous chemicals, and its risk is not familiar and understood by many users, which often leads to decomposition and poisoning accidents. Therefore, it is of great practical significance to study the hazards and safety measures in the use of Triphosgene. Based on the characteristic identification of triphosgene, the hazards in the process of dissolution and reaction are identified and analyzed, and the corresponding safety measures in the use of Triphosgene are put forward according to the results of hazard identification and analysis. Triphosgene has gradually become the raw material for acyl chlorination in many enterprises because it is a non hazardous chemical, relatively stable material properties, easy transportation and easy treatment of tail gas. However, if the safety measures are not appropriate during the transportation, storage and use of triphosgene, it is very easy to cause poisoning accidents.

Description

Triphosgene is also known as solid phosgene. Its chemical name is bis (Trichloromethyl) carbonate, and its English name is bisgriehloromethyl) carbonate or triphosgene, abbreviated as BTC. Triphosgene is a white crystal, similar to the smell of phosgene. It is mainly used to synthesize chloroformate, isocyanate, polycarbonate and acyl chloride. It is widely used as an intermediate in plastics, medicine, herbicides and pesticides.

Chemical Properties

White solid

Uses

Different sources of media describe the Uses of 32315-10-9 differently. You can refer to the following data:
1. An efficient carbonylating agent for liquid and solid-phase aza-peptide synthesis.
2. Triphosgene is used as a carbonylating agent for aza-peptide synthesis. It reacts with several alfa-amino acids to give the corresponding N-carboxyanhydrides. It is involved in the preparation of the esterification coupling reagent, di-2-thienyl carbonate from 2(5H)-thiophenone. Further, it is used as a reagent in organic synthesis and converts an amino group into isocyanate. In addition to this, it is employed in the preparation of 2-chloronicotinaldehydes through cyclization of the corresponding enamides. It is considered as a useful substitute for phosgene.
3. Triphosgene can be employed as a reagent to prepare: Thiocarbonates from thiols and alcohols by one-pot, three-component reaction.Substituted azetidin-2-ones from acids and imines via ketene–imine cycloaddition reaction. Methyl (S)-2-isocyanato-3-phenylpropanoate from L-phenylalanine methyl ester hydrochloride in the presence of sodium bicarbonate. Acyl azides derivatives from various carboxylic acids and sodium azide. Immunosuppressant agent cyclosporin by solid-phase peptide synthesis.Allyl azides from allyl alcohols and sodium azide in one pot method.Esterification coupling reagent di-2-thienyl carbonate, from 2(5H)-thiophenone.2-Chloronicotinaldehydes via cyclization of the corresponding enamides.

Reactions

The Triphosgene reaction is quenched very carefully by dropwise addition of 75 mL of saturated aqueous sodium sulfate solution ?(Notes 5 and 6). The resulting white granular precipitate or slurry is ?removed by vacuum filtration through Celite, and the filter cake is ?washed with three portions of 75 mL of chloroform .

General Description

Triphosgene [Bis(trichloromethyl)carbonate] is a versatile organic reagent used in organic synthesis alternative to phosgene. A catalytic amount of triphosgene is particularly used in chloroformylations, carbonylations, chlorinations, and dehydration reactions.

Safety

Triphosgene's low vapor pressure makes it possible for it to reach concentrations that are considered toxicologically unsafe. While several properties of triphosgene are not yet readily available, it is known that it is extremely toxic if inhaled. A toxic gas is emitted if it comes in contact with water. There is a lack of information and variability regarding the proper handling of triphosgene. It is assumed to have the same risks as phosgene.

Synthesis

Triphosgene?is synthesized by exhaustive free radical chlorination of dimethyl carbonate:CH3OCO2CH3 + 6 Cl2 → CCl3OCO2CCl3 + 6 HClTriphosgene can be easily recrystallized from hot hexanes.

Purification Methods

It is a good solid substitute for phosgene (using a third mol per mol). Crystallise it from pet ether (b 60-80o), wash it with anhydrous cold Et2O, de-gas it at 200mm then dry at 0.1mm (over H2SO4). It has IR: max 900 and 1900 cm-1 . It is a lachrymator, is TOXIC and should be handled with gloves and in an efficient fume hood. [Hales et al. J Chem Soc 620 1957, Eckert & Forster Angew Chem, Int Ed Engl 26 894 1987, Aldrichimica Acta 21 47 1988, Beilstein 3 H 17, 3 I 8, 3 II 16, 3 III 36, 3 IV 33.]

Check Digit Verification of cas no

The CAS Registry Mumber 32315-10-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,3,1 and 5 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 32315-10:
(7*3)+(6*2)+(5*3)+(4*1)+(3*5)+(2*1)+(1*0)=69
69 % 10 = 9
So 32315-10-9 is a valid CAS Registry Number.
InChI:InChI=1/C3Cl6O3/c4-2(5,6)11-1(10)12-3(7,8)9

32315-10-9 Well-known Company Product Price

  • Brand
  • (Code)Product description
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  • Detail
  • TCI America

  • (T1467)  Triphosgene  >98.0%(T)

  • 32315-10-9

  • 25g

  • 230.00CNY

  • Detail
  • TCI America

  • (T1467)  Triphosgene  >98.0%(T)

  • 32315-10-9

  • 250g

  • 980.00CNY

  • Detail
  • Aldrich

  • (330752)  Triphosgene  reagent grade, 98%

  • 32315-10-9

  • 330752-5G

  • 423.54CNY

  • Detail
  • Aldrich

  • (330752)  Triphosgene  reagent grade, 98%

  • 32315-10-9

  • 330752-25G

  • 1,185.21CNY

  • Detail
  • Aldrich

  • (330752)  Triphosgene  reagent grade, 98%

  • 32315-10-9

  • 330752-100G

  • 5,440.50CNY

  • Detail
  • Aldrich

  • (330752)  Triphosgene  reagent grade, 98%

  • 32315-10-9

  • 330752-500G

  • 11,003.85CNY

  • Detail
  • Aldrich

  • (15217)  Bis(trichloromethyl)carbonate  purum, ≥99.0% (AT)

  • 32315-10-9

  • 15217-10G

  • 1,076.40CNY

  • Detail
  • Aldrich

  • (15217)  Bis(trichloromethyl)carbonate  purum, ≥99.0% (AT)

  • 32315-10-9

  • 15217-50G

  • 3,142.62CNY

  • Detail

32315-10-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name bis(trichloromethyl) carbonate

1.2 Other means of identification

Product number -
Other names Methanol, trichloro-, carbonate (2:1)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:32315-10-9 SDS

32315-10-9Synthetic route

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

Conditions
ConditionsYield
With chlorine In tetrachloromethane for 18h; Irradiation;100%
With chlorine In tetrachloromethane for 28h; Irradiation;97%
With chlorine for 33h; chlorination;88%
carbonic acid chloromethyl ester-dichloromethyl ester
207804-71-5

carbonic acid chloromethyl ester-dichloromethyl ester

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

Conditions
ConditionsYield
bei der Chlorierung;
methyl 1,1,1-trichloromethyl carbonate
101970-86-9

methyl 1,1,1-trichloromethyl carbonate

A

carbonic acid chloromethyl ester-trichloromethyl ester

carbonic acid chloromethyl ester-trichloromethyl ester

B

carbonic acid dichloromethyl ester-trichloromethyl ester

carbonic acid dichloromethyl ester-trichloromethyl ester

C

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

Conditions
ConditionsYield
Chlorierung;
methyl 1,1,1-trichloromethyl carbonate
101970-86-9

methyl 1,1,1-trichloromethyl carbonate

A

carbonic acid dichloromethyl ester-trichloromethyl ester

carbonic acid dichloromethyl ester-trichloromethyl ester

B

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

Conditions
ConditionsYield
Chlorierung;
methyl 1,1,1-trichloromethyl carbonate
101970-86-9

methyl 1,1,1-trichloromethyl carbonate

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

Conditions
ConditionsYield
bei Chlorierung;
durch Chlorierung;
methyl chloroformate
79-22-1

methyl chloroformate

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

Conditions
ConditionsYield
vollstaendiges Chlorierung;
chlorothio-trichloro-methane
594-42-3

chlorothio-trichloro-methane

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

Conditions
ConditionsYield
With sulfur dioxide In dichloromethane; water at 10℃; for 4h;
cis-1,2-cyclohexane
1792-81-0

cis-1,2-cyclohexane

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

(3aR,7aS)-hexahydrobenzo[d][1,3]dioxol-2-one
4389-22-4, 19456-20-3, 20192-66-9

(3aR,7aS)-hexahydrobenzo[d][1,3]dioxol-2-one

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃;100%
With pyridine In dichloromethane at -70℃;90%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

(-)-menthol
2216-51-5

(-)-menthol

(1R,2S,5R)-menthyl chloroformate
14602-86-9

(1R,2S,5R)-menthyl chloroformate

Conditions
ConditionsYield
With pyridine In tetrachloromethane at 55 - 60℃; for 6h;100%
Stage #1: bis(trichloromethyl) carbonate With pyridine In toluene at 0℃; for 0.25h; Inert atmosphere;
Stage #2: (-)-menthol In toluene at 20℃; for 15h; Inert atmosphere;
100%
Stage #1: bis(trichloromethyl) carbonate With pyridine In toluene at 0℃; Inert atmosphere;
Stage #2: (-)-menthol In toluene at 0 - 20℃; Inert atmosphere;
100%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

1-adamantanol
700-57-2

1-adamantanol

2-adamantyl chloroformate
53120-53-9

2-adamantyl chloroformate

Conditions
ConditionsYield
With pyridine In dichloromethane for 2h; Ambient temperature;100%
With pyridine In dichloromethane for 1h; Ambient temperature;
With pyridine In dichloromethane; ethyl acetate
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

benzylamine
100-46-9

benzylamine

benzyl isothiocyanate
3173-56-6

benzyl isothiocyanate

Conditions
ConditionsYield
With triethylamine In dichloromethane100%
In ethyl acetate for 4h; Heating;56%
With triethylamine In dichloromethane for 1h; Heating;
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

β-cyanoethyl chlorocarbonate
30436-27-2

β-cyanoethyl chlorocarbonate

Conditions
ConditionsYield
Stage #1: bis(trichloromethyl) carbonate; 3-Hydroxypropionitrile In tetrahydrofuran at 0 - 20℃;
Stage #2: With pyridine In tetrahydrofuran at 0 - 20℃;
100%
In pyridine; toluene at 0℃;
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

(-)-(2R,3S,6S)-2-hydroxymethyl-3-methyl-6-phenyl-4-piperidone
181783-40-4

(-)-(2R,3S,6S)-2-hydroxymethyl-3-methyl-6-phenyl-4-piperidone

(2R,3S,6S)-1-aza-3-methyl-6-phenyl-8-oxa-4,7-dioxobicyclo[4.3.0]nonane
181783-52-8

(2R,3S,6S)-1-aza-3-methyl-6-phenyl-8-oxa-4,7-dioxobicyclo[4.3.0]nonane

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 0.25h;100%
1-dodecyl alcohol
112-53-8

1-dodecyl alcohol

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

n-dodecyl chloroformate
24460-74-0

n-dodecyl chloroformate

Conditions
ConditionsYield
With pyridine In tetrachloromethane at -15 - 20℃;100%
With pyridine In tetrahydrofuran for 2h;
With pyridine In chloroform for 2h; ice cooling;
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

5,17-diamino-25,26,27,28-tetrakis(propyloxy)calix[4]arene
156874-49-6, 169436-70-8, 950744-70-4, 1078151-72-0

5,17-diamino-25,26,27,28-tetrakis(propyloxy)calix[4]arene

5,17-bis(isocyanato)-25,26,27,28-tetrapropoxy[4]arene
199923-86-9

5,17-bis(isocyanato)-25,26,27,28-tetrapropoxy[4]arene

Conditions
ConditionsYield
In toluene Heating;100%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

cis-2-hydroxycyclohexanecarbonitrile
70367-35-0

cis-2-hydroxycyclohexanecarbonitrile

C8H10ClNO2

C8H10ClNO2

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃;100%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

(1S,4aR,5S,6S,9R,10R,11S,12S,12aS)-1,12-(Isopropylidenedioxy)-9,12a,13,13-tetramethyl-4-methylenetetradecahydro-6,10-methanobenzocyclodecene-5,6,9,10,11-pentaol
202340-92-9

(1S,4aR,5S,6S,9R,10R,11S,12S,12aS)-1,12-(Isopropylidenedioxy)-9,12a,13,13-tetramethyl-4-methylenetetradecahydro-6,10-methanobenzocyclodecene-5,6,9,10,11-pentaol

(4S,4aS,5S,6S,7R,8R,11S,12S,12aR)-11,12-(Carbonyldioxy)-4,5-(isopropylidenedioxy)-4a,8,13,13-tetramethyl-1-methylenetetradecahydro-7,11-methanobenzocyclodecene-5,7,8-triol
222727-00-6

(4S,4aS,5S,6S,7R,8R,11S,12S,12aR)-11,12-(Carbonyldioxy)-4,5-(isopropylidenedioxy)-4a,8,13,13-tetramethyl-1-methylenetetradecahydro-7,11-methanobenzocyclodecene-5,7,8-triol

Conditions
ConditionsYield
With pyridine In dichloromethane at -45℃;100%
With pyridine In dichloromethane at -45℃; for 1.16667h; Acylation; Cyclization;100%
N-methylcyclohexylamine
100-60-7

N-methylcyclohexylamine

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

N-methyl-N-cyclohexylaminocarbonyl chloride
35028-38-7

N-methyl-N-cyclohexylaminocarbonyl chloride

Conditions
ConditionsYield
With pyridine In toluene100%
With pyridine In toluene
With pyridine In dichloromethane at 20℃; for 2h;
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

D-serine methyl ester
2104-89-4, 2788-84-3, 24184-43-8

D-serine methyl ester

(R)-2-oxo-oxazolidine-4-carboxylic acid methyl ester
144542-43-8

(R)-2-oxo-oxazolidine-4-carboxylic acid methyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane 0-5 deg C, 2 h; room temperature, 48 h;100%
In tetrahydrofuran at 65℃; for 4h;
In tetrahydrofuran at 65℃; for 4h; Condensation;
With potassium carbonate In toluene at 20℃;
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

labda-12,14-dien-7α,8α-diol

labda-12,14-dien-7α,8α-diol

labda-12,14-dien-7α,8α-cyclocarbonate
220595-40-4

labda-12,14-dien-7α,8α-cyclocarbonate

Conditions
ConditionsYield
With pyridine In dichloromethane at -78 - 0℃; for 4h;100%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

(1S,3S)-1-{(1S,2S)-1,3-Bis-(3,4-dimethoxy-phenyl)-2-[(S)-2-(1H-indol-3-yl)-1-methoxycarbonyl-ethylamino]-propyl}-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester
234117-19-2

(1S,3S)-1-{(1S,2S)-1,3-Bis-(3,4-dimethoxy-phenyl)-2-[(S)-2-(1H-indol-3-yl)-1-methoxycarbonyl-ethylamino]-propyl}-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester

(1S,2S,6S,12bS)-2-(3,4-Dimethoxy-benzyl)-1-(3,4-dimethoxy-phenyl)-3-[(S)-2-(1H-indol-3-yl)-1-methoxycarbonyl-ethyl]-4-oxo-1,2,3,4,6,7,12,12b-octahydro-pyrimido[1',6':1,2]pyrido[3,4-b]indole-6-carboxylic acid methyl ester

(1S,2S,6S,12bS)-2-(3,4-Dimethoxy-benzyl)-1-(3,4-dimethoxy-phenyl)-3-[(S)-2-(1H-indol-3-yl)-1-methoxycarbonyl-ethyl]-4-oxo-1,2,3,4,6,7,12,12b-octahydro-pyrimido[1',6':1,2]pyrido[3,4-b]indole-6-carboxylic acid methyl ester

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane at 20℃; Cyclization;100%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

aniline
62-53-3

aniline

phenyl isocyanate
103-71-9

phenyl isocyanate

Conditions
ConditionsYield
With triethylamine In dichloromethane100%
In ethyl acetate at 0 - 5℃; for 3h; Solvent; Cooling with ice; Reflux;89%
In chloroform at 20℃; for 1h; Cooling with ice;85%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

p-aminoiodobenzene
540-37-4

p-aminoiodobenzene

1-iodo-4-isocyanatobenzene
15845-62-2

1-iodo-4-isocyanatobenzene

Conditions
ConditionsYield
With triethylamine In dichloromethane100%
In ethyl acetate for 4h; Heating;74%
With triethylamine In dichloromethane at -35 - 20℃; for 2h;60%
meta-fluoroaniline
372-19-0

meta-fluoroaniline

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

1-fluoro-3-isocyanatobenzene
404-71-7

1-fluoro-3-isocyanatobenzene

Conditions
ConditionsYield
With triethylamine In dichloromethane100%
With triethylamine In benzene for 3h; Heating;75%
With triethylamine In benzene acylation; Heating;41%
2-Fluoroaniline
348-54-9

2-Fluoroaniline

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

1-Fluoro-2-isocyanato-benzene
16744-98-2

1-Fluoro-2-isocyanato-benzene

Conditions
ConditionsYield
With triethylamine In dichloromethane100%
With triethylamine In benzene for 3h; acylation; Heating;36%
With triethylamine In benzene for 3h; Condensation; Heating;32%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

4-fluoroaniline
371-40-4

4-fluoroaniline

para-fluorophenyl isocyanate
1195-45-5

para-fluorophenyl isocyanate

Conditions
ConditionsYield
With triethylamine In dichloromethane100%
With triethylamine In toluene for 7h; Reflux; Cooling with ice;76.6%
In 1,4-dioxane at 80℃; for 24h;73.1%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

tert-butyl 4-aminobenzoate
18144-47-3

tert-butyl 4-aminobenzoate

4-nitro-aniline
100-01-6

4-nitro-aniline

1-(4'-nitrophenyl)-3-(4''-tert-butylcarboxyphenyl)urea
301317-92-0

1-(4'-nitrophenyl)-3-(4''-tert-butylcarboxyphenyl)urea

Conditions
ConditionsYield
Stage #1: bis(trichloromethyl) carbonate; 4-nitro-aniline With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 20℃; for 0.833333h; Substitution;
Stage #2: tert-butyl 4-aminobenzoate In tetrahydrofuran at 20℃; for 42h; Substitution;
100%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

tert-butyl 4-(chlorocarbonyl)piperazine-1-carboxylate
59878-28-3

tert-butyl 4-(chlorocarbonyl)piperazine-1-carboxylate

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere;100%
With pyridine In dichloromethane at 0 - 25℃; for 1h;89%
Stage #1: 1-t-Butoxycarbonylpiperazine With pyridine In dichloromethane at 0℃; for 0.166667h; Inert atmosphere;
Stage #2: bis(trichloromethyl) carbonate In dichloromethane at 0℃; for 1h; Inert atmosphere;
86%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

anthranilic acid
118-92-3

anthranilic acid

isatoic anhydride
118-48-9

isatoic anhydride

Conditions
ConditionsYield
In tetrahydrofuran at 45℃; for 12h;100%
In 1,2-dichloro-ethane for 3.25h; Reflux;96%
In tetrahydrofuran for 4h; Reflux;95%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

(+/-)-trans-2-methylcyclohexanol
7443-52-9

(+/-)-trans-2-methylcyclohexanol

allyl α-syn-oximino-α-(2-pyridyl)acetate
355023-73-3

allyl α-syn-oximino-α-(2-pyridyl)acetate

allyl α-syn-[(trans-2-methylcyclohexyloxy)carbonyl]oximino-α-(2-pyridyl)acetate

allyl α-syn-[(trans-2-methylcyclohexyloxy)carbonyl]oximino-α-(2-pyridyl)acetate

Conditions
ConditionsYield
Stage #1: bis(trichloromethyl) carbonate; (+/-)-trans-2-methylcyclohexanol With pyridine In dichloromethane at 50℃; for 1.5h;
Stage #2: allyl α-syn-oximino-α-(2-pyridyl)acetate With triethylamine In dichloromethane at 25℃; for 1.5h; Further stages.;
100%
2,6-diethylaniline
579-66-8

2,6-diethylaniline

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

2,6-diethylphenylisocyanate
20458-99-5

2,6-diethylphenylisocyanate

Conditions
ConditionsYield
With triethylamine In 1,2-dichloro-ethane Heating;100%
With triethylamine In 1,2-dichloro-ethane
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

5-monoamino-25,26,27,28-tetrakis(propyloxy)-calix[4]arene
199923-84-7

5-monoamino-25,26,27,28-tetrakis(propyloxy)-calix[4]arene

C41H47NO5
496067-40-4

C41H47NO5

Conditions
ConditionsYield
In toluene Heating;100%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

2-[(1S,5S,7R)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-6-aza-spiro[4.5]dec-7-yl]-ethanol
498542-65-7

2-[(1S,5S,7R)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-6-aza-spiro[4.5]dec-7-yl]-ethanol

C29H39NO3Si
498542-66-8

C29H39NO3Si

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃;100%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

m-Anisidine
536-90-3

m-Anisidine

3-methoxyphenyl isocyanate
18908-07-1

3-methoxyphenyl isocyanate

Conditions
ConditionsYield
With triethylamine In dichloromethane100%
In dichloromethane at 20℃; for 1.5h;
In toluene at 100℃; Cooling with ice;
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

2-methoxy-phenylamine
90-04-0

2-methoxy-phenylamine

1-Isocyanato-2-methoxy-benzene
700-87-8

1-Isocyanato-2-methoxy-benzene

Conditions
ConditionsYield
With triethylamine In dichloromethane100%
In dichloromethane at 20℃; for 1.5h;
In dichloromethane at 0℃; for 0.5h;
With triethylamine In 1,2-dichloro-ethane at 0 - 85℃; for 8.5h; Inert atmosphere;
With triethylamine In 1,2-dichloro-ethane at 0 - 85℃; for 8.5h; Inert atmosphere;
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

4-methoxy-aniline
104-94-9

4-methoxy-aniline

4-Methoxyphenyl isocyanate
5416-93-3

4-Methoxyphenyl isocyanate

Conditions
ConditionsYield
With triethylamine In dichloromethane100%
Stage #1: bis(trichloromethyl) carbonate; 4-methoxy-aniline In dichloromethane at 20℃; for 0.5h;
Stage #2: With triethylamine In dichloromethane at -35 - 20℃; for 2h;
92%
In chloroform at 20℃; for 1h; Cooling with ice;85%

32315-10-9Relevant articles and documents

PROCESS FOR SYNTHESIS OF FIPRONIL

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Page/Page column 22-23, (2011/10/03)

A process for preparation of a trifluoromethylsulfinyl pyrazole compound of formula (I) from a compound of formula (III) is provided, wherein R, R1 and R2 represent a group containing halogen respectively and R3 represents a perhaloalkyl.

Carbamazepine derivatives

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, (2008/06/13)

The present invention provides a novel carbamazepine hydrazide compound suitable for covalent attachment to a polymer particle reagent, having the general formula STR1 The present invention also provides a novel carbamazepine acid compound suitable for attachment to proteins for the production of carbamazepine immunogens. The carbamazepine antigen of the present invention has the following general structure: STR2 where X is C=O, CH2 or SO2 ; Y is C=O, CH2, SO2 ; R is an alkyl and P is a protein or a hapten.

Physostigmine derivatives.

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, (2008/06/13)

Physostigmine derivatives are described of the general formula: in which R is a linear or branched alkyl with three to nine C atoms, or benzyl, and their slats with pharmaceutically acceptable acids, which are particularly useful for the preparation of pharmaceutical compositions having a acetylcholinesterase inhibiting function

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