60-27-5 Usage
Description
Creatinine is a breakdown product formed by the degradation of creatine phosphate from muscles. It is a normal constituent of urine and is also found in muscle tissues and blood. Creatinine is a white powder and is the most widely known "uremic toxin", often assessed when a reduction in kidney function is suspected. It is a heterocyclic nitrogenous compound that produces electron-rich and highly basic creatinine derivatives in chemical synthesis.
Uses
1. Creatinine is used as a metabolic enhancer for its role in the end product of creatine catabolism.
2. It is used in the medical field as a measure of renal function, as creatinine levels in blood and urine may be used to calculate the creatinine clearance (CrCl), which reflects the glomerular filtration rate (GFR), an important clinical index of renal function.
3. Creatinine is used as a substrate for creatininase in various biochemical processes.
Used in Pharmaceutical Industry:
Creatinine is used as a diagnostic marker for assessing kidney function and estimating the glomerular filtration rate (eGFR), which is crucial in the development of drugs and therapies targeting renal diseases.
Used in Chemical Synthesis:
Creatinine is used as a heterocyclic nitrogenous compound to produce electron-rich and highly basic creatinine derivatives, which can be utilized in the synthesis of various pharmaceuticals and chemicals.
Used in Research and Development:
Creatinine is used as a research tool to study the effects of creatine supplementation on muscle metabolism and its implications on athletic performance and overall health.
Used in Environmental Science:
Creatinine is found in all soils, grain seeds, and other vegetable matter, as well as in certain fish and crab meat extract. It can be used as an indicator of organic matter content and nutrient cycling in various ecosystems.
Biological Functions
Creatinine is a byproduct of a chemical compound called creatine, which helps muscles get the energy that they need. As a waste product, creatinine is filtered out of the blood by the kidneys and removed from the body in urine.A creatinine test measures the amount of this chemical in either the blood or urine. Creatinine levels can provide an indication of how well the kidneys are working.Creatinine may be measured alone or included in a panel of tests that include other compounds found in the urine or blood.https://labtestsonline.org/tests/creatininehttps://www.kidney.org/atoz/content/what-creatinine
Purification Methods
Likely impurities are creatine and ammonium chloride. Dissolve it in dilute HCl, then neutralise with ammonia. Recrystallise it from H2O by adding excess of Me2CO. The picrate crystallises from 23volumes of boiling H2O and has m 220-221o(dec). [King J Chem Soc 2377 1930, Beilstein 25 III/IV 2543.]
Check Digit Verification of cas no
The CAS Registry Mumber 60-27-5 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 0 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 60-27:
(4*6)+(3*0)+(2*2)+(1*7)=35
35 % 10 = 5
So 60-27-5 is a valid CAS Registry Number.
InChI:InChI=1/C4H7N3O/c1-7-2-3(8)6-4(7)5/h2H2,1H3,(H2,5,6,8)/p+1
60-27-5Relevant articles and documents
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Hongo
, p. 279,289 (1935)
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Lundquist
, p. 98 (1947)
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A preparation method of creatinine
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Paragraph 0014; 0028-0042; 0055; 0056, (2019/03/31)
The invention belongs to the technical field of chemical synthesis, in particular relates to a preparation method of creatinine, the method to creatine as the starting material, and containing 2 - 5 carbon of the lower saturated fatty acid reaction. The method of environmental protection, without by-product to produce, almost zero-emission, without refining can be directly used for cardiac muscle protective drug creatine phosphate sodium synthetic.
METHOD FOR PREPARING CREATINE FATTY ESTERS, CREATINE FATTY ESTERS THUS PREPARED AND USES THEREOF
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Page/Page column 26, (2014/02/16)
The present invention concerns a method for preparing a creatine fatty ester or derivative thereof comprising at least one step consisting in reacting a diprotected creatinine with a molecule bearing at least one alcohol functional group and of formula R'-OH in which R' represents a hydrocarbon radical containing at least 4 carbon atoms. The present invention also concerns particular creatine fatty esters or derivative thereof and medical uses thereof.