623-26-7Relevant articles and documents
Solvent effects in simple fast electron transfer reactions
Winkler, Krzysztof,Baranski, Andrzej S.,Fawcett, W. Ronald
, p. 3899 - 3904 (1996)
The kinetics of the one-electron reduction of p-dicyanobenzene and the oxidation of nickelocene have been studied by ac voltammetry in different aprotic solvents at mercury and platinum ultramicroelectrodes. The observed electron transfer rate constants have been corrected for the double-layer effect. The solvent dependences of the electron transfer rate constants and activation enthalpy are interpreted within the context of contemporary theory. The charge transfer process was found to be perfectly adiabatic for both studied systems. Solvent dynamic and Gibbs activation energy effects on the rate constants were also investigated.
The self-assembly and metal adatom coordination of a linear bis-tetrazole ligand on Ag(111)
Knecht, Peter,Suryadevara, Nithin,Zhang, Bodong,Reichert, Joachim,Ruben, Mario,Barth, Johannes V.,Klyatskaya, Svetlana,Papageorgiou, Anthoula C.
, p. 10072 - 10075 (2018)
We employ a linear linker molecule consisting of a benzene functionalised with two tetrazole moieties at para positions. Its self-assembly and coordination with the native silver adatoms and codeposited Fe adatoms on a Ag(111) surface under ultra high vacuum conditions are investigated by means of scanning tunnelling microscopy and X-ray photoelectron spectroscopy. We discover a rich spectrum of room-temperature stable Ag and Fe2+ coordination nodes depending on the formation temperature.
Electrochemically Catalyzed Aromatic Nucleophilic Substitution. Reactivity of Cyanide Ions toward Aryl Radicals in Liquid Ammonia
Amatore, Christian,Combellas, Catherine,Robveille, Sabine,Saveant, Jean-Michel,Thiebault, Andre
, p. 4754 - 4760 (1986)
The mechanism of the substitution of a series of aromatic halides by cyanide ion under electrochemical induction is described as a function of the substrate.The rate constants of the addition of cyanide ion on eight aryl radicals have been determined by using either a direct or a competitive electrochemical method.The variation of the reactivity toward the CN- ions with the structure of the aryl radicals is discussed.
Synthesis, Biological Activity, and Molecular Docking Assessment of Some New Sulfonylated Tetrazole Derivatives
Arshad,Khan,Nami
, p. 1851 - 1858 (2019)
The designed molecular structures have been subjected to computational analysis for calculating their physicochemical properties and drug likeness. The calculated data indicate that most of the compound possess the bioactivity score in the active zone. Synthetic approach to the target compounds is straightforward and easy to handle. Structures of the new compounds are supported by FT-IR, 1H, and 13C NMR, and mass spectra. Antimicrobial tests of the products against pathogens (S. aureus, S. epidermidis, E. coli, and P. mirabilis) indicate the products as active or highly active. Their cyto-toxicity is determined to be 92–98% at concentration of 3.125 μmol/L. The molecular docking analysis carried out for the target compounds against the receptor Glc-N-6P exhibits low binding energy and various binding sites of those.
Synthesis, Characterization, and Catalytic Study of Caffeine-Derived N-heterocyclic Carbene Palladium Complexes
Chen, Haiqun,Huynh, Han Vinh,Liu, Ziwei,Lu, Yuchen,Meng, Qi,Teng, Qiaoqiao,Yuan, Dan,Zhao, Yaru
, p. 161 - 168 (2022/02/07)
Homo- and heterodicarbene palladium complexes bearing caffeine-derived N-heterocyclic carbene ligands were synthesized and fully characterized by NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis. The superior acidity of the alkylated ca
Nitrile Synthesis via Desulfonylative-Smiles Rearrangement
Abe, Masahiro,Nitta, Sayasa,Miura, Erina,Kimachi, Tetsutaro,Inamoto, Kiyofumi
, p. 4460 - 4467 (2022/03/15)
Herein, we designed a simple nitrile synthesis from N-[(2-nitrophenyl)sulfonyl]benzamides via base-promoted intramolecular nucleophilic aromatic substitution. The process features redox-neutral conditions as well as no requirement of toxic cyanide species and transition metals. Our process shows broad scope and various functional group compatibility, affording a variety of (hetero)aromatic nitriles in good to excellent yields.
Facile dehydration of primary amides to nitriles catalyzed by lead salts: The anionic ligand matters
Ruan, Shixiang,Ruan, Jiancheng,Chen, Xinzhi,Zhou, Shaodong
, (2020/12/09)
The synthesis of nitrile under mild conditions was achieved via dehydration of primary amide using lead salts as catalyst. The reaction processes were intensified by not only adding surfactant but also continuously removing the only by-product, water from the system. Both aliphatic and aromatic nitriles can be prepared in this manner with moderate to excellent yields. The reaction mechanisms were obtained with high-level quantum chemical calculations, and the crucial role the anionic ligand plays in the transformations were revealed.
METHOD FOR PRODUCING NITRILE
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Paragraph 0080; 0090, (2021/02/05)
The present invention provides a method of producing a nitrile from a primary amide, characterized in that the primary amide is subjected to a dehydration reaction in a supercritical fluid in the presence of an acid catalyst. The present invention achieves the object of reducing the corrosion of a reactor and the thermal decomposition of raw materials, as well as provides the effect of improving the reaction rate and nitrile selectivity.
Efficient nitriding reagent and application thereof
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Paragraph 0209-0211, (2021/03/31)
The invention discloses an efficient nitriding reagent and application thereof, wherein the nitriding reagent comprises nitrogen oxide, an active agent, a reducing agent and an organic solvent. By applying the nitriding reagent, nitrogen-containing compounds such as amide, nitrile and the like can be produced, and the method is simple in condition, low in waste discharge amount and simple in reaction equipment.
Visible-Light-Promoted Metal-Free Synthesis of (Hetero)Aromatic Nitriles from C(sp3)?H Bonds**
Murugesan, Kathiravan,Donabauer, Karsten,K?nig, Burkhard
supporting information, p. 2439 - 2445 (2020/12/07)
The metal-free activation of C(sp3)?H bonds to value-added products is of paramount importance in organic synthesis. We report the use of the commercially available organic dye 2,4,6-triphenylpyrylium tetrafluoroborate (TPP) for the conversion of methylarenes to the corresponding aryl nitriles via a photocatalytic process. Applying this methodology, a variety of cyanobenzenes have been synthesized in good to excellent yield under metal- and cyanide-free conditions. We demonstrate the scope of the method with over 50 examples including late-stage functionalization of drug molecules (celecoxib) and complex structures such as l-menthol, amino acids, and cholesterol derivatives. Furthermore, the presented synthetic protocol is applicable for gram-scale reactions. In addition to methylarenes, selected examples for the cyanation of aldehydes, alcohols and oximes are demonstrated as well. Detailed mechanistic investigations have been carried out using time-resolved luminescence quenching studies, control experiments, and NMR spectroscopy as well as kinetic studies, all supporting the proposed catalytic cycle.
