929-06-6

Usage

Uses

Used in Cosmetics Industry:
2-Aminoethoxyethanol is used as a solvent for [application reason] in the cosmetics industry. Its ability to dissolve various substances makes it suitable for use in formulations of personal care products.
Used in Detergent Industry:
2-Aminoethoxyethanol is used as a solvent for [application reason] in the detergent industry. It helps in dissolving and stabilizing various components in detergent formulations.
Used in Paint Industry:
2-Aminoethoxyethanol is used as a solvent for [application reason] in the paint industry. It aids in the dispersion and solubility of pigments and other ingredients in paint formulations.
Used in Pesticide Formulations:
2-Aminoethoxyethanol is used as a stabilizer for [application reason] in pesticide formulations. It helps in maintaining the stability and effectiveness of the pesticides.
Used in Pharmaceutical Manufacturing:
2-Aminoethoxyethanol is used as a solvent or intermediate in the manufacturing of pharmaceuticals for [application reason]. Its ability to dissolve various substances makes it useful in the production of certain drugs.
Used in Textile Chemicals:
2-Aminoethoxyethanol is used as a solvent or processing aid in the textile industry for [application reason]. It helps in the application of dyes, finishes, and other chemicals to textiles during manufacturing processes.

InChI:InChI=1/C4H11NO2/c1-4(6)7-3-2-5/h4,6H,2-3,5H2,1H3

Synthetic route

2-(2-azidoethoxy)ethanol (139115-90-5) → 2-(2-Aminoethoxy)ethanol (929-06-6)

Conditions	Yield
With water; triphenylphosphine In tetrahydrofuran for 4h; Ambient temperature;	99%
With 10% palladium on activated charcoal; hydrogen In methanol under 760.051 Torr; for 8h;	98.3%
With palladium on activated charcoal; hydrogen In methanol	19.4 g

2-(2-phthalimidoethoxy)ethanol (69676-63-7) → 2-(2-Aminoethoxy)ethanol (929-06-6)

Conditions	Yield
With hydrazine hydrate In ethanol at 90℃; for 24h;	74%

C23H21F17N2O7 (1548723-17-6) → 2-(2-Aminoethoxy)ethanol (929-06-6)

Conditions	Yield
With benzylamine In dichloromethane for 1.5h; UV-irradiation;	15%

N-(2-(2-hydroxyethoxy)ethyl)acetamide (118974-46-2) → 2-(2-Aminoethoxy)ethanol (929-06-6)

Conditions	Yield
With hydrogenchloride; ethanol

diethylene glycol (111-46-6) → 2-(2-Aminoethoxy)ethanol (929-06-6)

Conditions	Yield
With nickel kieselguhr; ammonia at 205℃;
iron-containing catalyst Product distribution / selectivity;
With ammonia; hydrogen; (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In toluene at 155℃; under 44254.4 Torr; for 12h; Product distribution / selectivity; Autoclave; Cooling;

2-(2-nitro-ethoxy)-ethanol (20132-16-5) → 2-(2-Aminoethoxy)ethanol (929-06-6)

Conditions	Yield
With hydrogen; nickel In ethanol

2-(2-Chloroethoxy)ethanol (628-89-7) → 2-(2-Aminoethoxy)ethanol (929-06-6)

Conditions	Yield
With ammonia In ethanol

C5H10NO4(1-) (207116-18-5) → carbon dioxide (124-38-9) + 2-(2-Aminoethoxy)ethanol (929-06-6)

Conditions	Yield
In water at 33.6 - 75.9℃; Thermodynamic data; Equilibrium constant; ΔH,ΔG, ΔS;

N,N'-bis(2,3-dihydroxypropyl)-5-(2-{[2-(2-hydroxyethoxy)ethyl]amino}-2-oxoethoxy)-1,3-benzenedicarboxamide → [3,5-Bis-(2,3-dihydroxy-propylcarbamoyl)-phenoxy]-acetic acid + 2-(2-Aminoethoxy)ethanol (929-06-6)

Conditions	Yield
With water at 95℃; Rate constant;

ammonia (7664-41-7) + diethylene glycol (111-46-6) + nickel + kieselguhr → morpholine (110-91-8) + 2-(2-Aminoethoxy)ethanol (929-06-6) + amine

Conditions	Yield
at 205℃;

C5H10NO4(1-) (207116-18-5) → hydrogen carbonate (71-52-3) + 2-(2-Aminoethoxy)ethanol (929-06-6)

Conditions	Yield
In water at 26.85℃; Equilibrium constant; Further Variations:; Temperatures;

diethylene glycol (111-46-6) → morpholine (110-91-8) + 2-methoxy-ethanol (109-86-4) + ethylamine (75-04-7) + 2-methoxyethylamine (109-85-3) + 2-(2-Aminoethoxy)ethanol (929-06-6)

Conditions	Yield
With ammonia; hydrogen In water at 190℃; Product distribution / selectivity;
With ammonia; hydrogen In water at 200℃; Product distribution / selectivity;

ethenol (557-75-5) + sodium carbonate (497-19-8) + 2-(2-Chloroethoxy)ethanol (628-89-7) → 2-(2-Aminoethoxy)ethanol (929-06-6)

Conditions	Yield
With ammonia	16.4 g (43%)

diethylene glycol (111-46-6) → morpholine (110-91-8) + 2-(2-Aminoethoxy)ethanol (929-06-6)

Conditions	Yield
With ammonia; hydrogen; catalyst containing 28.1percent by weight of Ni, calculated as NiO; 27.7percent by weight of Co, calculated as CoO; 13.1percent by weight of Cu, calculated as CuO; 31.2percent by weight of Zr, calculated as ZrO2 mixed with graphite at 192 - 198℃; under 150015 Torr; Product distribution / selectivity;
With ammonia; hydrogen; catalyst comprising 20.3 weight percent Ni, 20.2 weight percent Co, 10.6 weight percent Cu, 7.5 weight percent Mo, reminder up to 100percent is ZrO2 at 200℃; under 135014 - 150015 Torr; for 12h; Product distribution / selectivity; Autoclave;
With ammonia; hydrogen; 22.0 wtpercent NiO/21.5 wtpercent CoO/10.5 wtpercent CuO/0.6 wtpercent Bi2O3/ZrO2 at 200℃; under 135014 - 150015 Torr; for 10h; Product distribution / selectivity;	A 20.9 %Chromat. B 34.6 %Chromat.

diethylene glycol (111-46-6) → morpholine (110-91-8) + N-ethylmorpholine; (100-74-3) + 2-(2-Aminoethoxy)ethanol (929-06-6)

Conditions	Yield
With ammonia; fixed-bed catalyst at 215℃; under 150015 Torr; Hydrogen atmosphere;

diethylene glycol (111-46-6) → morpholine (110-91-8) + 2-methoxy-ethanol (109-86-4) + 2-(2-Aminoethoxy)ethanol (929-06-6)

Conditions	Yield
With ammonia; hydrogen at 200℃; under 135014 - 150015 Torr; for 12h; Autoclave;	A 18.2 %Chromat. B 0.2 %Chromat. C 26.3 %Chromat.

diethylene glycol (111-46-6) → morpholine (110-91-8) + 2,2'-diaminodiethyl ether (2752-17-2) + 2-(2-Aminoethoxy)ethanol (929-06-6)

Conditions	Yield
With ammonia; C28H44BNOP2Ru In toluene at 155℃; under 30528.1 Torr; for 12h; Product distribution / selectivity; Autoclave; Inert atmosphere;
With ammonia; chlorocarbonylhydrido[4,5-bis(dicyclohexylphosphinomethyl)acridine]ruthenium(II) In para-xylene at 155℃; under 33003.3 Torr; for 24h; Product distribution / selectivity; Autoclave; Inert atmosphere;
With ammonia; chlorocarbonylhydrido[4,5-bis(dicyclohexylphosphinomethyl)acridine]ruthenium(II) In toluene at 155℃; under 32253.2 Torr; for 12h; Product distribution / selectivity; Autoclave;

diethylene glycol (111-46-6) → 2,2'-diaminodiethyl ether (2752-17-2) + 2-(2-Aminoethoxy)ethanol (929-06-6)

Conditions	Yield
With ammonia; hydrogen; chlorocarbonylhydrido[4,5-bis(dicyclohexylphosphinomethyl)acridine]ruthenium(II) In toluene at 135℃; under 42829.3 Torr; for 12h; Product distribution / selectivity; Autoclave; Cooling;
With chlorocarbonylhydrido[4,5-bis(dicyclohexylphosphinomethyl)acridine]ruthenium(II); ammonia at 155℃; for 12h; Inert atmosphere; Autoclave;

phthalic anhydride (85-44-9) + 2-(2-Aminoethoxy)ethanol (929-06-6) → 2-(2-phthalimidoethoxy)ethanol (69676-63-7)

Conditions	Yield
In toluene for 4h; Heating;	100%
In toluene for 4h; Reflux;	100%
In toluene for 24h; Reflux;	100%

di-tert-butyl dicarbonate (24424-99-5) + 2-(2-Aminoethoxy)ethanol (929-06-6) → 2-(2-tert-butyloxycarbonylaminoethoxy)ethanol (139115-91-6)

Conditions	Yield
In dichloromethane at 20℃;	100%
In tetrahydrofuran; water at 20℃; for 16h;	100%
In ethanol at 0 - 20℃; for 2h; Inert atmosphere;	100%

benzyl chloroformate (501-53-1) + 2-(2-Aminoethoxy)ethanol (929-06-6) → 2-<2-N-(benzyloxycarbonyl)aminoethoxy>ethanol (145881-74-9)

Conditions	Yield
In 2-methyl-THF at 10 - 20℃;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 20h;	97%
With triethylamine In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;	96%

2-([(tert-butoxy)carbonyl]{2-[(4-methoxybenzyl)amino]-2-oxoethyl}amino)acetic acid (194996-03-7) + 2-(2-Aminoethoxy)ethanol (929-06-6) → {[2-(2-Hydroxy-ethoxy)-ethylcarbamoyl]-methyl}-[(4-methoxy-benzylcarbamoyl)-methyl]-carbamic acid tert-butyl ester (194996-45-7)

Conditions	Yield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; for 16h; Substitution;	100%
With N,N-diethyl-N-isopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate In N,N-dimethyl-formamide at 25℃; for 16h;	7%

N-((tert-butyloxy)carbonyl)-N'-(2-(3-methoxyphenyl)ethyl)iminodiacetic acid monoamide (188625-13-0) + 2-(2-Aminoethoxy)ethanol (929-06-6) → {[2-(2-Hydroxy-ethoxy)-ethylcarbamoyl]-methyl}-{[2-(3-methoxy-phenyl)-ethylcarbamoyl]-methyl}-carbamic acid tert-butyl ester (194996-44-6)

Conditions	Yield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; for 16h; Substitution;	100%
With N,N-diethyl-N-isopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate In N,N-dimethyl-formamide at 25℃; for 16h;	13%

N-((tert-butyloxy)carbonyl)-N'-(5-((benzyloxycarbonyl)amino)-5-(methoxycarbonyl)pentyl)iminodiacetic acid monoamide (206867-09-6) + 2-(2-Aminoethoxy)ethanol (929-06-6) → 2-benzyloxycarbonylamino-6-[2-(tert-butoxycarbonyl-{[2-(2-hydroxy-ethoxy)-ethylcarbamoyl]-methyl}-amino)-acetylamino]-hexanoic acid methyl ester

Conditions	Yield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; for 16h; Substitution;	100%

N-((tert-butyloxy)carbonyl)-N'-(4-(1',4'-dioxolano)piperidino)iminodiacetic acid monoamide (215161-22-1) + 2-(2-Aminoethoxy)ethanol (929-06-6) → [2-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-2-oxo-ethyl]-{[(3-hydroxy-propoxymethyl)-carbamoyl]-methyl}-carbamic acid tert-butyl ester

Conditions	Yield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; for 16h; Substitution;	100%

ethyl trifluoroacetate, (383-63-1) + 2-(2-Aminoethoxy)ethanol (929-06-6) → 2,2,2-trifluoro-N-[2-(2-hydroxyethoxy)-ethyl]acetamide (302331-18-6)

Conditions	Yield
In methanol	100%
With triethylamine In methanol at 20℃;	83%
In methanol at 20℃; for 3h;	80%
With triethylamine In methanol at 20℃; for 3h;	80%
With triethylamine for 24h;	161 g

benzyl bromide (100-39-0) + 2-(2-Aminoethoxy)ethanol (929-06-6) → 2-(N,N-dibenzyl-2-aminoethoxy)ethanol (136533-09-0)

Conditions	Yield
With potassium carbonate In acetonitrile for 2h; Reflux;	100%
With potassium carbonate In acetonitrile at 50 - 55℃; for 3.5h;	97%
With potassium carbonate In acetonitrile Reflux;	89.2%

acrylic acid methyl ester (292638-85-8) + 2-(2-Aminoethoxy)ethanol (929-06-6) → 3-[[2-(2-hydroxy-ethoxy)-ethyl]-(2-methoxycarbonyl-ethyl)-amino]-propionoic acid methyl ester (921227-43-2)

Conditions	Yield
In methanol at 20℃; for 48h; Michael addition;	100%
In methanol at 30℃; for 72h; Inert atmosphere;	99%

2-(2-Aminoethoxy)ethanol (929-06-6) → 2-(2-aminoethoxy)ethanol hydrochloride (40321-53-7)

Conditions	Yield
With hydrogenchloride In ethanol at 0℃; for 0.5h;	100%
With hydrogenchloride In methanol for 0.5h;

NaHCO3 (saturated) + di-tert-butyl dicarbonate (24424-99-5) + 2-(2-Aminoethoxy)ethanol (929-06-6) → 2-(2-tert-butyloxycarbonylaminoethoxy)ethanol (139115-91-6)

Conditions	Yield
In tetrahydrofuran	100%

2-(2-Aminoethoxy)ethanol (929-06-6) + n-hexadecanoyl chloride (112-67-4) → N-(ω-hydroxyethoxyethyl)hexadecanamide (20138-27-6)

Conditions	Yield
Stage #1: 2-(2-Aminoethoxy)ethanol With magnesium oxide In tetrahydrofuran; water at 5℃; for 0.5h; Stage #2: n-hexadecanoyl chloride In tetrahydrofuran; water at 5 - 10℃; for 2h;	100%
With triethylamine In dichloromethane at 0℃; for 4h;	92%
With magnesium oxide In tetrahydrofuran; water

4-carboxybenzophenone (611-95-0) + 2-(2-Aminoethoxy)ethanol (929-06-6) → C18H19NO4 (1579942-48-5)

Conditions	Yield
Stage #1: 4-carboxybenzophenone With ammonium bicarbonate In 1,4-dioxane for 2h; Stage #2: 2-(2-Aminoethoxy)ethanol In 1,4-dioxane for 2h;	100%

C18H21N3O4 + 2-(2-Aminoethoxy)ethanol (929-06-6) → C13H19NO3

Conditions	Yield
In methanol at 20℃; for 0.5h;	100%

tert-butyldicarbonate (34619-03-9) + 2-(2-Aminoethoxy)ethanol (929-06-6) → 2-(2-Boc-aminoethoxy)-ethanol

Conditions	Yield
In chloroform	99%

perylene-3,4,9,10-tetracarboxylic acid 3,4:9,10-dianhydride (128-69-8) + 2-(2-Aminoethoxy)ethanol (929-06-6) → 2,9-bis(2-(2-hydroxyethoxy)ethyl)anthra[2,1,9-def:6,5,10-d'e'f']diisoquinoline-1,3,8,10(2H,9H)-tetraone (238755-74-3)

Conditions	Yield
In N,N-dimethyl-formamide at 200℃; for 0.966667h; Microwave irradiation;	99%
at 130℃; for 3h;	94%
at 130℃; for 3h; Inert atmosphere;
With N,N-dimethyl acetamide; zinc diacetate at 160℃; for 8h; Inert atmosphere;

ethyl 1-(2-bromoethyl)-3-(4-methoxyphenyl)-1H-pyrazole-5-carboxylate (1101861-36-2) + 2-(2-Aminoethoxy)ethanol (929-06-6) → 5-(2-(2-hydroxyethoxy)ethyl)-2-(4-methoxyphenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one (1310071-15-8)

Conditions	Yield
With potassium iodide for 0.0166667h; Microwave irradiation;	99%

(adamant-1-yl)-acetic acid (4942-47-6) + 2-(2-Aminoethoxy)ethanol (929-06-6) → C16H27NO3

Conditions	Yield
With benzotriazol-1-ol; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine In dichloromethane	99%

2-(2-Aminoethoxy)ethanol (929-06-6) + formic acid ethyl ester (109-94-4) → N-[2-(2-hydroxyethoxy)ethyl]formamide

Conditions	Yield
at 90℃; for 6h;	99%
at 90℃; for 6h; Inert atmosphere;	99%

trans-4-cycloocten-yl 2,5-dioxo-1-pyrrolidinyl ester carbonic acid + 2-(2-Aminoethoxy)ethanol (929-06-6) → C13H23NO4

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 0.5h;	98.8%

C13H17NO5 + 2-(2-Aminoethoxy)ethanol (929-06-6) → C13H23NO4

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 0.5h;	98.8%

acetic anhydride (108-24-7) + 2-(2-Aminoethoxy)ethanol (929-06-6) → N-(2-(2-hydroxyethoxy)ethyl)acetamide (118974-46-2)

Conditions	Yield
In ethanol for 0.5h; Heating;	98%
In ethanol at 40℃; for 0.25h;	97%
With dmap; triethylamine In chloroform at 65℃; for 2.5h;	92%

tert-butylchlorodiphenylsilane (58479-61-1) + 2-(2-Aminoethoxy)ethanol (929-06-6) → 2-(2'-tert-butyldiphenylsiloxyethoxy)ethylamine

Conditions	Yield
With 1H-imidazole for 18h;	98%

p-methyl red (201858-51-7) + 2-(2-Aminoethoxy)ethanol (929-06-6) → 4-(4-dimethylamino-phenylazo)-N-[2-(2-hydroxy-ethoxy)-ethyl]-benzamide

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide Acylation;	98%
Stage #1: p-methyl red With triethylamine; isobutyl chloroformate In tetrahydrofuran at 20℃; for 2h; Stage #2: 2-(2-Aminoethoxy)ethanol In tetrahydrofuran for 0.5h;

1,4,5,8-naphthalenetetracarboxylic dianhydride (81-30-1) + 2-(2-Aminoethoxy)ethanol (929-06-6) → 2,7-bis(2-(2-hydroxyethoxy)ethyl)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone (164932-87-0)

Conditions	Yield
In 1-methyl-pyrrolidin-2-one at 100℃; for 2h;	98%
In ethanol Reflux;	89.1%
With pyridine; zinc diacetate amidation; Heating;	70%

4-cyanobenzoic Acid (619-65-8) + 2-(2-Aminoethoxy)ethanol (929-06-6) → 4-cyano-N-[2-(2-hydroxy-ethoxy)-ethyl]-benzamide

Conditions	Yield
Stage #1: 4-cyanobenzoic Acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane for 2h; Stage #2: 2-(2-Aminoethoxy)ethanol With sodium carbonate In water for 1h; Further stages.;	98%

4-bromo-1,8-naphthalenedicarboxylic anhydride (81-86-7) + 2-(2-Aminoethoxy)ethanol (929-06-6) → 2-[2-(2-hydroxy-ethoxy)-ethyl]-6-[2-(2-hydroxy-ethoxy)-ethylamino]-benzo[de]isoquinoline-1,3-dione (903499-39-8)

Conditions	Yield
In 1-methyl-pyrrolidin-2-one at 110℃; for 2h;	98%

Adipic acid (124-04-9) + di-β-aminoethyl oxalate dihydrochloride + 1,2-dichloro-ethane (107-06-2) + 2-(2-Aminoethoxy)ethanol (929-06-6) → di-β-(β-ethoxy)-ethyl adipate dihydrochloride

Conditions	Yield
In hydrogenchloride	98%

Upstream product

• 111-46-6 diethylene glycol 
• 20132-16-5 2-(2-nitro-ethoxy)-ethanol 
• 628-89-7 2-(2-Chloroethoxy)ethanol 
• 207116-18-5 C₅H₁₀NO₄^(1-) 
• 139115-90-5 2-(2-azidoethoxy)ethanol 
• 7664-41-7 ammonia 
• 557-75-5 ethenol 
• 497-19-8 sodium carbonate 
• 1548723-17-6 C₂₃H₂₁F₁₇N₂O₇ 
• 69676-63-7 2-(2-phthalimidoethoxy)ethanol 
• 118974-46-2 N-[2-(2-hydroxyethoxy)ethyl]acetamide 

Downstream Products

• 54384-48-4 tris-[2-(2-hydroxy-ethoxy)-ethyl]-amine 
• 783-88-0 N-<2-(2-hydroxyethoxy)ethyl>-4-methylbenzenesulfonamide 
• 123845-23-8 N-{2-[2-(2-Hydroxy-ethoxy)-ethylamino]-ethyl}-4-methyl-benzenesulfonamide 
• 118974-46-2 N-[2-(2-hydroxyethoxy)ethyl]acetamide 
• 54384-47-3 2,2'-((azanediylbis(ethane-2,1-diyl))bis(oxy))diethanol 
• 124243-65-8 N-<2-(2-hydroxyethoxy)ethyl>benzamide 
• 136538-57-3 2-fluoro-N-<2-(2'-hydroxyethyl)ethoxy>benzamide 
• 82654-75-9 1,4-dihydroxy-5,8-bis<<2-(2-hydroxyethoxy)ethyl>amino>-9,10-antracenedione 
• 124042-44-0 1,3:4,6-bis<3,3':6,6'-bis<1,4,10,13-tetraoxa-7-(5-hydroxy-3-oxapent-1-yl)-7-azatridecamethylene>-1,2-xylylene>tetrahydro-3a,6a-diphenylimidazo<4,5-d>imidazole-2,5(1H,3H)-dione 
• 20138-27-6 N-(ω-hydroxyethoxyethyl)hexadecanamide 
• 145881-74-9 2-<2-N-(benzyloxycarbonyl)aminoethoxy>ethanol 
• 180967-91-3 {(S)-1-[2-(2-Hydroxy-ethoxy)-ethylcarbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester 
• 221541-14-6 2-[2-(2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl)ethoxy]ethanol 
• 56739-35-6 3-[2-(2-hydroxy-ethoxy)-ethyl]-1-(3-nitro-phenyl)-1H-quinazoline-2,4-dione 

Relevant academic research and scientific papers

Supramolecular compound nano-carrier as well as preparation method and application thereof

The invention discloses a supramolecular compound nano-carrier as well as a preparation method and application thereof, and relates to the technical field of polymer chemistry and biological detection engineering. According to the supramolecular compound nano-carrier disclosed by the invention, a two-dimensional nanosheet supramolecular structure system generated by self-assembly is driven by an anion induction effect, and a supramolecular compound nano-carrier is of a single-layer nanosheet supramolecular structure constructed by a highly-oriented one-dimensional nanorod. A hydrophobic perylene group part is used as a skeleton part for constructing the highly-oriented one-dimensional nanorod, and the charge density of a single-layer nanosheet can be regulated and controlled. The surface of the water-soluble multivalent hydrophilic part can be loaded with DNAzyme deoxyribozyme for specific detection of heavy metal ions through electrostatic interaction, and the water-soluble multivalent supramolecular compound nano sensor is constructed. Based on a fluorescence change mechanism caused by specific cutting of heavy metal ions, The fluorescence detection of the heavy metal ions in food and biological tissues is realized, and the detection effect of the heavy metal ions is greatly enhanced.

SYNTHESIS OF 2-(2-AMINOETHOXY) ETHANOL

A method for synthesizing 2-(2-aminoethoxy) ethanol, including the steps of producing 2-(2-phthalimidoethoxy) ethanol by reacting 5-tosyloxy-3-oxapentanol with potassium phthalate and converting the 2-(2-phthalimidoethoxy) ethanol to the 2-(2-aminoethoxy) ethanol by reacting the 2-(2-phthalimidoethoxy) ethanol with hydrazine monohydrate. Reacting the 2-(2-phthalimidoethoxy) ethanol with the hydrazine monohydrate may include forming a final mixture by adding the hydrazine monohydrate to a solution of 2-(2-phthalimidoethoxy) ethanol, refluxing the final mixture in a nitrogen atmosphere, extracting a second organic phase containing the 2-(2-aminoethoxy) ethanol from the final mixture using a second portion of chloroform, and purifying the 2-(2-aminoethoxy) ethanol from the second organic phase.

EXENATIDE MODIFIER AND USE THEREOF

Disclosed are an exenatide modifier for connecting the exenatide to a fatty chain with a carboxy in the terminus thereof by means of a hydrophilic connecting arm, and a use thereof in preparing drugs serving as a GLP-1 receptor agonist; a use in preparing drugs for preventing and/or treating diseases and/or symptoms associated with a low GLP-1 receptor activity; a use in preparing drugs for diseases and/or symptoms associated with glycometabolism; a use in preparing drugs for diabetes; a use in preparing drugs for fatty liver disease, and a use in preparing drugs for losing weight.

mellow amination by homogeneous catalysis of the method for the production of primary amines

The invention relates to a method for producing primary amines by means of the alcohol amination of alcohols with ammonia, with water being eliminated. The method comprises the steps of: (a) a homogenously-catalysed reaction of a reaction mixture which contains at least one alcohol, ammonia, at least one non-polar solvent, and at least one catalyst containing at least one element selected from groups 8, 9 and 10 of the periodic table in the liquid phase, a product mixture (P) thus being obtained; (b) separating the phases of product mixture (P) which was obtained in step (a), if necessary after a reduction in temperature, a reduction in pressure and/or the addition of at least one polar solvent with a miscibility gap in relation to the non-polar solvent, and thus obtaining at least one polar product phase (A) and at least one non-polar phase (B) containing at least one portion of the catalyst that was introduced, with said non-polar phase (B) being separated off, (c) returning at least one portion of the non-polar phase (B) into the reaction in step (a), and (d) separating the amination product from the polar product phase (A). The non-polar solvent introduced in (a) and the catalyst introduced in step (a) are selected such that the catalyst in the non-polar phase (B) becomes enriched.

METHOD FOR PRODUCING ALKANOL AMINES BY HOMOGENEOUSLY CATALYZED ALCOHOL AMINATION

PROBLEM TO BE SOLVED: To provide a method for producing alkanol amines by alcohol amination of diols using ammonia under elimination of water. SOLUTION: The invention relates to a method for producing alkanol amines which comprise a primary amino group (-NH2) and a hydroxyl group (-OH), by alcohol amination of diols comprising two hydroxyl groups (-OH) using ammonia under elimination of water. The reaction is homogeneously catalyzed in the presence of at least one complex catalyst which contains at least one element selected from groups 8, 9 and 10 of the periodic table and at least one donor ligand. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPO&INPIT

The preparation obtained by homogeneous catalysis mellow amination method of the primary amine

The invention relates to a method for producing primary amines comprising at least one functional group of formula (-CH2-NH2), by alcohol amination of educts which comprise at least one functional group of formula (-CH2-OH), using ammonia, and elimination of water. The homogeneously catalyzed alcohol amination is carried out in the presence of at least one complex catalyst which contains at least one element selected from the groups 8 and 9 of the periodic table and at least one phosphorus donor ligand of general formula (I).

· Uniform catalyst by using alcohol aminosilicone di-, tri-and a method of manufacturing a polyphenylenepolyamine

The invention relates to a method for producing primary amines, which contain at least one functional group of the formula (-CH2-NH2) and at least one further primary amino group, by the alcohol amination of reactants, which contain at least one functional group of the formula (-CH2-OH) and at least one further functional group (-X), wherein (-X) is selected from hydroxyl groups and primary amino groups, using ammonia with removal of water, wherein the reaction is carried out in a homogeneously catalyzed manner in the presence of at least one complex catalyst containing at least one element selected from groups 8, 9 and 10 of the periodic table and at least one donor ligand.

Synthesis of fluorous photolabile aldehyde and carbamate and alkyl carbamate protecting groups for carbohydrate-associated amines

Two new fluorous photolabile-protecting groups (FNBC and FNB) and a new base-labile protecting group (FOC) for the masking of amines are reported. The protecting groups survive a wide range of common reaction conditions used in oligosaccharide synthesis and render the attached molecules amenable to fluorous solid-phase extraction (FSPE). A glycosyl acceptor containing the FNB group is shown to be useful in the synthesis of carbohydrates tagged with free deactivated secondary amines.

PROCESS FOR THE PREPARATION OF PRIMARY AMINES BY HOMOGENEOUSLY CATALYZED ALCOHOL AMINATION

Preparing a primary amine by alcohol amination of alcohol with ammonia and elimination of water includes reacting, in a homogeneously catalyzed reaction, a mixture of alcohol, ammonia, nonpolar solvent, and catalyst, in a liquid phase, to obtain a product mixture. The process then includes phase separating the product mixture into a polar product phase and a nonpolar product phase, and separating off the nonpolar product phase. At least some of the nonpolar phase returns to the homogenously catalyzed reaction. The process further includes separating off amination product from the polar product phase. At least some of the catalyst is in the nonpolar phase, and the catalyst accumulates in the nonpolar phase.

PROCESS FOR PREPARING ALKANOLAMINES BY HOMOGENEOUSLY CATALYZED ALCOHOL AMINATION

Process for preparing alkanolamines which have a primary amino group (—NH2) and a hydroxyl group (—OH) by alcohol amination of diols having two hydroxyl groups (—OH) by means of ammonia with elimination of water, wherein the reaction is carried out homogeneously catalyzed in the presence of at least one complex catalyst comprising at least one element selected from groups 8, 9 and 10 of the Periodic Table and also at least one donor ligand.