Inhibition of NADH oxidation by 1-methyl-4-phenylpyridinium analogs as the basis for the prediction of the inhibitory potency of novel compounds

DOI: 10.1002/(SICI)1522-7146(1996)11:1<33::AID-JBT5>3.0.CO;2-W

Source and publish data:

Journal of biochemical toxicology p. 33 - 43 (1996)

Update date:2022-08-04

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Authors:

Sablin, Sergey O.

Krueger, Matthew J.

Yankovskaya, Victoria L.

Tkachenko, Sergey E.

Razdolsky, Alexander N.

Bachurin, Sergey O.

Ramsay, Rona R.

Singer, Thomas P.

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Article abstract of DOI:10.1002/(SICI)1522-7146(1996)11:1<33::AID-JBT5>3.0.CO;2-W

Inhibition of NADH dehydrogenase (Complex I) of the mitochondrial respiratory chain by 1-methyl-4-phenylpyridinium (MPP⁺) and its analogs results in dopaminergic cell death. In the present study, the inhibition of mitochondrial respiration and

Full text of DOI:10.1002/(SICI)1522-7146(1996)11:1<33::AID-JBT5>3.0.CO;2-W

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