(6R,6S)-5,8,10-Trideaza-5,6,7,8-tetrahydrofolate and (6R,6S)-5,8,10-Trideaza-5,6,7,8-tetrahydropteroyl-L-ornithine as Potential Antifolates and Antitumor Agents

DOI: 10.1021/jm00123a037

Source and publish data:

Journal of Medicinal Chemistry p. 709 - 715 (1989)

Update date:2022-08-04

Topics:

Authors:

Rosowsky, Andre

Forsch, Ronald A.

Moran, Richard G.

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Article abstract of DOI:10.1021/jm00123a037

(6R,6S)-5,8,10-Trideaza-5,6,7,8-tetrahydropteroic acid was synthesized in several steps from 4,4-(ethylenedioxy)cyclohexanone and <4-(tert-butyloxycarbonyl)benzyl>triphenylphosphonium bromide and was elaborated to (6R,6S)-5,8,10-trideaza-5,6,7,8-tetrahydr

Full text of DOI:10.1021/jm00123a037

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