Enantioselective synthesis of 1S, 3S, 5S- and 1R, 3S, 5R-2-Azabicyclo[3.3.0]octane-3-carboxylic acid starting from L-serine

Article abstract of DOI:10.3987/COM-88-S111

(1S, 3S, 5S)- and (1R, 3S, 5R)-2-Azabicyclo[3.3.0]octane-3-carboxylic acid have been synthesized by intramolecular radical cyclisation of methyl 2-(S)-[N-benzyloxycarbonyl-N-(2-cyclopenten-l-yl)amino]-3-iodopropionate and subsequent reactions.