Total Synthesis of (+/-)-12-Hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic Acid (12-HETE)

DOI: 10.1021/jo00222a054

Source and publish data:

Journal of Organic Chemistry p. 4417 - 4418 (1985)

Update date:2022-08-03

Topics:

Authors:

Gunn, Bruce P.

Brooks, Dee W.

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Article abstract of DOI:10.1021/jo00222a054

A total synthesis of 12-HETE is reported which incorporates an oxidative cleavage of an appropriately substituted furan to provide a functionalized trans-allylhydroxy fragment which is subsequently elaborated in an operationally simple manner affording a practical preparation of 12-HETE.

Full text of DOI:10.1021/jo00222a054

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