Total Synthesis of (+/-)-12-Hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic Acid (12-HETE)

Article abstract of DOI:10.1021/jo00222a054

A total synthesis of 12-HETE is reported which incorporates an oxidative cleavage of an appropriately substituted furan to provide a functionalized trans-allylhydroxy fragment which is subsequently elaborated in an operationally simple manner affording a practical preparation of 12-HETE.