Diastereoselective Conjugate Addition of Cyclic Hydrazine to Optically Active Vinyl Sulfoxide. A Novel Synthesis of Optically Active Azalactams

Article abstract of DOI:10.1246/cl.1990.1547

Optically active (R)-(+)-1,5-diaza-4-phenylbicyclo<4.3.0>nonan-2-one (5) was prepared in high optical purity by diastereoselective conjugate addition of piperidazine to optically active (E)-(S)-1-(methoxycarbonyl)-2-phenylvinyl p-tolyl sulfoxide, followed