Isolation of an isomer of FK-506 from fermentation of Streptomyces tsukubaensis and its chemical synthesis from FK-506

DOI: 10.1016/S0040-4020(01)89004-9

Source and publish data:

Tetrahedron p. 413 - 430 (1992)

Update date:2022-08-02

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Authors:

Grassberger, Maximilian A.

Fehr, Theodor

Horvath, Amarylla

Schulz, Gerhard

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Article abstract of DOI:10.1016/S0040-4020(01)89004-9

From the fermentation broth of Streptomyces tsukubaensis 9993 an isomer 2a of the immunosuppressant FK-506 1a was isolated as a minor metabolite. From NMR- and FAB-MS data follows that in 2a the size of the macrocycle is reduced by two carbon atoms due to

Full text of DOI:10.1016/S0040-4020(01)89004-9

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