Total Synthesis of Uracil Analogues of Sinefungin

DOI: 10.1021/jm00079a007

Source and publish data:

Journal of Medicinal Chemistry p. 63 - 67 (1992)

Update date:2022-07-29

Topics:

Authors:

Barton, Derek H. R.

Gero, Stephane D.

Lawrence, Francoise

Robert-Gero, Malka

Quiclet-Sire, Beatrice

Samadi, Mohammad

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Article abstract of DOI:10.1021/jm00079a007

Analogues of sinefungin derivatives 18a and 18b have been prepared from uridine and L-aspartic acid.The key step in the synthesis was the coupling of the radical derived from 14 with the unsaturated amide 13.THe latter was produced from the known N-hydrox

Full text of DOI:10.1021/jm00079a007

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Product name:benzyl 1'-uracil-1-yl-9'-<(benzyloxycarbonyl)amino>-6'(R or S)-<(tert-butoxycarbonyl)amino>-1',5',6',7',8',9'-hexadeoxy-2',3'-O-isopropylidene-β-D-ribo-1',4'-decafuranuronate

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