Synthesis of Optically Pure Fluoro- and gem-Chlorofluoro-cyclohexane Derivatives by Intramolecular Trapping of Dihaloalkyl Radicals.

Article abstract of DOI:10.1016/S0957-4166(00)82303-4

gem-Chlorofluorocyclohexanols 8 bearing a methyl and a p-tolylsulphinyl substituent have been obtained in a optically pure form by radical cyclization of corresponding halo-alkenes 4.Reductive dechlorination of both (6R)- and (6S)-8 gave fluoroderivative